4-Methoxyphenylacetic acid

Modify Date: 2025-08-21 09:10:58

4-Methoxyphenylacetic acid structure	Common Name	4-Methoxyphenylacetic acid
	CAS Number	104-01-8	Molecular Weight	166.174
	Density	1.2±0.1 g/cm3	Boiling Point	306.0±17.0 °C at 760 mmHg
	Molecular Formula	C₉H₁₀O₃	Melting Point	84-86 °C(lit.)
	MSDS	Chinese USA	Flash Point	124.3±14.4 °C
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of 4-Methoxyphenylacetic acid

2-(4-Methoxyphenyl)acetic acid is a plasma metabolite, with high sensitivity and specificity value as a biomarker for discriminating between NSCLC and healthy controls.

Name	4-methoxyphenylacetic acid
Synonym	More Synonyms

Description	2-(4-Methoxyphenyl)acetic acid is a plasma metabolite, with high sensitivity and specificity value as a biomarker for discriminating between NSCLC and healthy controls.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Cancer
Target	Human Endogenous Metabolite
In Vitro	2-(4-Methoxyphenyl)acetic acid (4-methoxyphenylacetic acid) is a plasma metabolite, with high sensitivity and specificity values as a biomarker for discriminating between NSCLC and healthy controls. 2-(4-Methoxyphenyl)acetic acid may play a protective role to prevent the development of lung cancer[1].
References	[1]. Xiang C, et al. Cortisol, cortisone, and 4-methoxyphenylacetic acid as potential plasma biomarkers for early detection of non-small cell lung cancer. Int J Biol Markers. 2018 Aug;33(3):314-320.

Density	1.2±0.1 g/cm3
Boiling Point	306.0±17.0 °C at 760 mmHg
Melting Point	84-86 °C(lit.)
Molecular Formula	C₉H₁₀O₃
Molecular Weight	166.174
Flash Point	124.3±14.4 °C
Exact Mass	166.062988
PSA	46.53000
LogP	1.42
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.538
Water Solubility	6 g/L (20 ºC)

4-Methoxyphenylacetic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AI8960000

CHEMICAL NAME :: Acetic acid, p-methoxyphenyl-

CAS REGISTRY NUMBER :: 104-01-8

BEILSTEIN REFERENCE NO. :: 1101737

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C9-H10-O3

MOLECULAR WEIGHT :: 166.19

WISWESSER LINE NOTATION :: QV1R DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0530656-1 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,685,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 504 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,709,1977 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83216 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 373 (estimated)

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AI8960000
HS Code	29189090

Precursor 9
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HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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2-(4-methoxyphenyl)acetic acid

Benzeneacetic acid, 4-methoxy-

4-Methoxyphenylacetic acid

EINECS 203-166-4

(4-Methoxyphenyl)acetic acid

QV1R DO1

Homoanisic Acid

MFCD00004345

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Price: ￥550/10 mM * 1 mL in DMSO

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4-Methoxyphenylacetic acid

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