tert-butyl N,N-bis(2-hydroxyethyl)carbamate

Modify Date: 2025-08-24 15:36:14

tert-butyl N,N-bis(2-hydroxyethyl)carbamate structure	Common Name	tert-butyl N,N-bis(2-hydroxyethyl)carbamate
	CAS Number	103898-11-9	Molecular Weight	205.25100
	Density	1.085	Boiling Point	324.2ºC at 760 mmHg
	Molecular Formula	C₉H₁₉NO₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	149.9ºC
	Symbol	GHS07	Signal Word	Warning

Use of tert-butyl N,N-bis(2-hydroxyethyl)carbamate

N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	N-BOC-Diethanolamine
Synonym	More Synonyms

Description	N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Philip Stewart Low, et al. Small molecule ligand-targeted drug conjugates for anti-influenza chemotherapy and immunotherapy. WO2020023323A1

Density	1.085
Boiling Point	324.2ºC at 760 mmHg
Molecular Formula	C₉H₁₉NO₄
Molecular Weight	205.25100
Flash Point	149.9ºC
Exact Mass	205.13100
PSA	70.00000
LogP	0.20810
Appearance of Characters	Liquid or Oil \| Colorless
Vapour Pressure	1.95E-05mmHg at 25°C
Index of Refraction	1.46

MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2924199090

Di-tert-butyl d...

CAS#:24424-99-5

dea

CAS#:111-42-2

~98%

tert-butyl N,N-...

CAS#:103898-11-9

Literature: Donaldson, Susan F.; Bergmeier, Stephen C.; Hines, Jennifer V.; Gerdeman, Melinda S. Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 2 p. 111 - 123

S-Boc-2-Mercapt...

CAS#:41840-28-2

dea

CAS#:111-42-2

tert-butyl N,N-...

CAS#:103898-11-9

Literature: US4987130 A1, ;

Precursor 3
CAS#:24424-99-5 Di-tert-butyl d... CAS#:111-42-2 dea CAS#:41840-28-2 S-Boc-2-Mercapt...
DownStream 2
CAS#:401518-12-5 1-BOC-4-CYANO-4... CAS#:401518-11-4 N-BOC-N,N-BIS{2...

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synthesis and antiviral activity of novel aza-acyclonucleosides.

Nucleosides Nucleotides 18 , 227, (1999)

We have prepared a series of novel aza-acyclonucleosides as potential antiviral agents. These compounds were prepared from diethanolamine and the desired purine or pyrimidine base via a Mitsunobu coup...

I. Solodin, T.D. Heath

Synlett , 617, (1996)

J.M. Orban et al.

J. Polym. Sci. A Polym. Chem. 37 , 3441, (1999)

MFCD01862953

N-Boc-diethanolamine

tert-Butyl bis(2-hydroxyethyl)carbamate

TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE