Sarecycline hydrochloride
Modify Date: 2024-01-02 06:53:22
Sarecycline hydrochloride structure
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Common Name | Sarecycline hydrochloride | ||
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| CAS Number | 1035979-44-2 | Molecular Weight | 523.963 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H30ClN3O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Sarecycline hydrochlorideSarecycline hydrochloride is a narrow-spectrum tetracycline-class antibiotic. Sarecycline hydrochloride possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains of Cutibacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome[1][2][3]. |
| Name | (4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide,hydrochloride |
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| Synonym | More Synonyms |
| Description | Sarecycline hydrochloride is a narrow-spectrum tetracycline-class antibiotic. Sarecycline hydrochloride possesses anti-inflammatory properties and potent activity against Gram-positive bacteria, including activity against multiple strains of Cutibacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome[1][2][3]. |
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| Related Catalog | |
| In Vitro | Sarecycline inhibits 55 clinical isolates of C. acnes, and the MIC values for Sarecycline ranged from 0.5 to 16 µg/ml; the MIC50 was 0.5 µg/ml, and the MIC90 was 4 µg/ml. Sarecycline, exhibits activity against the macrolide-resistant organisms[1]. Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria[2]. |
| In Vivo | Sarecycline hydrochloride (0.33-9 mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1]. Animal Model: Female SD-1 mice (A murine neutropenic thigh wound infection model)[1] Dosage: 0.33, 1, 3, or 9 mg/kg Administration: Intravenously Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively. |
| References |
| Molecular Formula | C24H30ClN3O8 |
|---|---|
| Molecular Weight | 523.963 |
| Exact Mass | 523.172119 |
| PSA | 174.85000 |
| LogP | 1.90890 |
| WC3035 |
| 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-, (4S,4aS,5aR,12aS)-, hydrochloride (1:1) |
| (4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-7-{[methoxy(methyl)amino]methyl}-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide hydrochloride (1:1) |
| SARECYCLINE HYDROCHLORIDE |
| P005672 HCl |
| Sarecycline HCl |