Niclofolan

Modify Date: 2024-01-02 16:32:55

Niclofolan structure	Common Name	Niclofolan
	CAS Number	10331-57-4	Molecular Weight	345.092
	Density	1.7±0.1 g/cm3	Boiling Point	424.9±45.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₆Cl₂N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	210.8±28.7 °C

Use of Niclofolan

Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection[1][2][3].

Name	4-chloro-2-(5-chloro-2-hydroxy-3-nitrophenyl)-6-nitrophenol
Synonym	More Synonyms

Description	Niclofolan (BAY 9015) is an orally active anthelmintic agent. Niclofolan can be used in the research of parasite infection[1][2][3].
Related Catalog	Research Areas >> Infection
In Vitro	Niclofolan (0.12 mg/mL, 60 min) is effective against Gyrodactylus sp. under in vitro conditions[3]. Cell Viability Assay[3] Cell Line: Gyrodactylus sp. (parasite) Concentration: 0.12 mg/mL Incubation Time: 60 min Result: Reduced the number of live Gyrodactylus sp. By 100%.
In Vivo	Niclofolan (2 mg/kg, intramuscular injection) is effective against fasciola hepatica infected sheep[2]. Niclofolan (1 or 2 mg/kg, oral gavage ) shows therapeutic effects against P.iloktsuenesis infected rats[4]. Animal Model: fasciola hepatica infected sheep[2] Dosage: 2 mg/kg Administration: Intramuscular injection Result: Showed effectiveness against the infection and produced no untoward effects except for transient signs of pain at the site of injection. Animal Model: Rats infected with P.iloktsuenesis[4] Dosage: 1 mg/kg, daily for 3 days; 2 mg/kg every other day for 2 times. Administration: Oral gavage Result: Reduced the worms in rats.
References	[1]. T Eckhardt, Treatment of human fascioliasis with niclofolan. Gastroenterology. 1981 Oct; 81(4):795-8. [2]. B H Ali, T Hassan, et al. The effect of niclofolan on desert sheep experimentally infected with immature Fasciola gigantica. J Vet Pharmacol Ther. 1985 Dec;8(4):398-403. [3]. Santamarina M. T., et al. Anthelmintic treatment against Gyrodactylus sp. infecting rainbow trout Oncorhynchus mykiss. Diseases of Aquatic Organisms, 1991 10(1): 39-43. [4]. Rim H J, et al. Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis. The Korean Journal of Parasitology, 1976, 14(2): 140-146.

Density	1.7±0.1 g/cm3
Boiling Point	424.9±45.0 °C at 760 mmHg
Molecular Formula	C₁₂H₆Cl₂N₂O₆
Molecular Weight	345.092
Flash Point	210.8±28.7 °C
Exact Mass	343.960297
PSA	132.10000
LogP	3.97
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.706

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV5075000

CHEMICAL NAME :: (1,1'-Biphenyl)-2,2'-diol, 5,5'-dichloro-3,3'-dinitro-

CAS REGISTRY NUMBER :: 10331-57-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C12-H6-Cl2-N2-O6

MOLECULAR WEIGHT :: 345.10

WISWESSER LINE NOTATION :: WNR DQ CG ER BQ CG ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 4,525,1971

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 13 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JETOAS Journal Europeen de Toxicologie. (Paris, France) V.1-6, 1968-72. For publisher information, see TOERD9. Volume(issue)/page/year: 4,525,1971

Hazard Codes	C
HS Code	2907299090

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Bayer 9015

EINECS 233-720-0

ME 3625

Bilevon M

5,5'-dichloro-3,3'-dinitro-2,2'-biphenyldiol

5,5'-dichloro-3,3'-dinitrobiphenyl-2,2'-diol

Niclofolanum [INN-Latin]

Niclofolano [INN-Spanish]

5,5'-Dichloro-3,3'-dinitro-[1,1'-biphenyl]-2,2'-diol

Niclofolan

BAY 9015

Menichlopholan

2,2'-Dihydroxy-3,3'-dinitro-5,5'-dichlor-diphenyl

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Niclofolan

Use of Niclofolan

Names

Niclofolan Biological Activity

Chemical & Physical Properties

Toxicological Information

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HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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