NSC-12

Modify Date: 2024-01-09 12:19:45

NSC-12 structure	Common Name	NSC-12
	CAS Number	102586-30-1	Molecular Weight	484.51500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₄F₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NSC-12

NSC 12 is an extracellular trap of fibroblast growth factor 2 (FGF2) that binds FGF2 and interferes with its interaction with FGFR1. NSC12 inhibits the proliferation of different FGF-dependent tumour cells both in vitro and in vivo with no systemic toxic effects[1].

Name	4,4,4-trifluoro-1-[(8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-3-(trifluoromethyl)butane-1,3-diol
Synonym	More Synonyms

Description	NSC 12 is an extracellular trap of fibroblast growth factor 2 (FGF2) that binds FGF2 and interferes with its interaction with FGFR1. NSC12 inhibits the proliferation of different FGF-dependent tumour cells both in vitro and in vivo with no systemic toxic effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Ronca R, et al. Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy. Cancer Cell. 2015 Aug 10;28(2):225-39.

Molecular Formula	C₂₄H₃₄F₆O₃
Molecular Weight	484.51500
Exact Mass	484.24100
PSA	60.69000
LogP	5.53300
Storage condition	-20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4816000

CHEMICAL NAME :: Pregn-5-ene-3,20-diol, 21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl)-

CAS REGISTRY NUMBER :: 102586-30-1

LAST UPDATED :: 198612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H34-F6-O3

MOLECULAR WEIGHT :: 484.58

WISWESSER LINE NOTATION :: L E5 B666 MUTJ A1 E1 FYQ1XQXFFFXFFF OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#09324

21-(Hydroxy(bistrifluoromethyl)methyl)pregnane-3,20-diol

Pregn-5-ene-3,20-diol,21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl)

NSC-12

DC Chemicals Limited
China
Product Name: NSC-12
Price: $950.0/100mg $1750.0/250mg $3500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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NSC-12

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CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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