TIE-2/VEGFR-2 kinase-IN-5

Modify Date: 2025-12-01 19:23:26

TIE-2/VEGFR-2 kinase-IN-5 structure	Common Name	TIE-2/VEGFR-2 kinase-IN-5
	CAS Number	1014407-83-0	Molecular Weight	481.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₁₃F₆N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TIE-2/VEGFR-2 kinase-IN-5

TIE-2/VEGFR-2 kinase-IN-5 is an anti-angiogenic agent. TIE-2/VEGFR-2 kinase-IN-5 also is a potent TIE-2 and VEGFR-2 tyrosine kinase inhibitor with pIC50 values of 7.78 nM and 8.11 nM, respectively. TIE-2/VEGFR-2 kinase-IN-5 can be used for the research of angiogenesis[1].

Name	TIE-2/VEGFR-2 kinase-IN-5

Description	TIE-2/VEGFR-2 kinase-IN-5 is an anti-angiogenic agent. TIE-2/VEGFR-2 kinase-IN-5 also is a potent TIE-2 and VEGFR-2 tyrosine kinase inhibitor with pIC50 values of 7.78 nM and 8.11 nM, respectively. TIE-2/VEGFR-2 kinase-IN-5 can be used for the research of angiogenesis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	Tie2:7.78 nM (IC50) VEGFR-2:8.11 nM (IC50)
References	[1]. Miyazaki Y, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8.

Molecular Formula	C₂₁H₁₃F₆N₅O₂
Molecular Weight	481.35
InChIKey	VLTNUYNTYZRWQD-UHFFFAOYSA-N
SMILES	Nc1ncnc2occ(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)cc(C(F)(F)F)c4)cc3)c12

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TIE-2/VEGFR-2 kinase-IN-5
Price: Check
Purity: 99.79%
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TIE-2/VEGFR-2 kinase-IN-5 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.