1014407-83-0

1014407-83-0 structure

Name: TIE-2/VEGFR-2 kinase-IN-5
Chemical Name: TIE-2/VEGFR-2 kinase-IN-5
CAS Number: 1014407-83-0
Molecular Formula: C₂₁H₁₃F₆N₅O₂
Molecular Weight: 481.35
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2023-09-20 19:44:20
Modify Date: 2024-04-05 18:47:24
TIE-2/VEGFR-2 kinase-IN-5 is an anti-angiogenic agent. TIE-2/VEGFR-2 kinase-IN-5 also is a potent TIE-2 and VEGFR-2 tyrosine kinase inhibitor with pIC50 values of 7.78 nM and 8.11 nM, respectively. TIE-2/VEGFR-2 kinase-IN-5 can be used for the research of angiogenesis[1].

Name	TIE-2/VEGFR-2 kinase-IN-5

Description	TIE-2/VEGFR-2 kinase-IN-5 is an anti-angiogenic agent. TIE-2/VEGFR-2 kinase-IN-5 also is a potent TIE-2 and VEGFR-2 tyrosine kinase inhibitor with pIC50 values of 7.78 nM and 8.11 nM, respectively. TIE-2/VEGFR-2 kinase-IN-5 can be used for the research of angiogenesis[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	Tie2:7.78 nM (IC50) VEGFR-2:8.11 nM (IC50)
References	[1]. Miyazaki Y, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8.

Molecular Formula	C₂₁H₁₃F₆N₅O₂
Molecular Weight	481.35