TIE-2/VEGFR-2 kinase-IN-5

Names

[ Name ]:
TIE-2/VEGFR-2 kinase-IN-5

Biological Activity

[Description]:

TIE-2/VEGFR-2 kinase-IN-5 is an anti-angiogenic agent. TIE-2/VEGFR-2 kinase-IN-5 also is a potent TIE-2 and VEGFR-2 tyrosine kinase inhibitor with pIC50 values of 7.78 nM and 8.11 nM, respectively. TIE-2/VEGFR-2 kinase-IN-5 can be used for the research of angiogenesis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

Tie2:7.78 nM (IC50)

VEGFR-2:8.11 nM (IC50)

[References]

[1]. Miyazaki Y, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₃F₆N₅O₂

[ Molecular Weight ]:
481.35

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.