4,4′-methylenedianiline

Modify Date: 2024-01-02 17:12:14

4,4′-methylenedianiline Structure
4,4′-methylenedianiline structure
 Common Name 4,4′-methylenedianiline
CAS Number 101-77-9 Molecular Weight 198.264
Density 1.15 Boiling Point 398-399 ºC (768 torr)
Molecular Formula C13H14N2 Melting Point 88-92 ºC
MSDS Chinese USA Flash Point 221 ºC
Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09		 Signal Word Danger

 Names

Name 4,4'-diaminodiphenylmethane
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.15
Boiling Point 398-399 ºC (768 torr)
Melting Point 88-92 ºC
Molecular Formula C13H14N2
Molecular Weight 198.264
Flash Point 221 ºC
Exact Mass 198.115692
PSA 52.04000
LogP 1.64
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.660

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BY5425000
CHEMICAL NAME :
Aniline, 4,4'-methylenedi-
CAS REGISTRY NUMBER :
101-77-9
BEILSTEIN REFERENCE NO. :
0474706
LAST UPDATED :
199806
DATA ITEMS CITED :
49
MOLECULAR FORMULA :
C13-H14-N2
MOLECULAR WEIGHT :
198.29
WISWESSER LINE NOTATION :
ZR D1R DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
8420 ug/kg
TOXIC EFFECTS :
Behavioral - rigidity (including catalepsy) Liver - jaundice, other or unclassified Liver - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
517 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
193 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
745 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
74 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16800 mg/kg/40W-C
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6972 mg/kg/12W-I
TOXIC EFFECTS :
Liver - other changes Blood - changes in spleen Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
456 mg/kg/15W-I
TOXIC EFFECTS :
Liver - fatty liver degeneration Kidney, Ureter, Bladder - interstitial nephritis Blood - normocytic anemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
320 mg/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1410 mg/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
DNA damage

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 108,225,1983 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.81 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,347,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,347,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: DE85-017376 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.8 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.81 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.8 mg/m3) JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.8 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.8 mg/m3);Skin;Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.8 mg/m3);STEL 0.5 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 4,4'-METHYLENEDIANILINE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83609 No. of Facilities: 363 (estimated) No. of Industries: 16 No. of Occupations: 27 No. of Employees: 9163 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83609 No. of Facilities: 741 (estimated) No. of Industries: 25 No. of Occupations: 30 No. of Employees: 15170 (estimated) No. of Female Employees: 3407 (estimated)

 Safety Information

Symbol GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
Signal Word Danger
Hazard Statements H317-H341-H350-H370-H373-H411
Precautionary Statements P201-P260-P273-P280-P308 + P313
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases R39/23/24/25;R43;R45;R48/20/21/22;R51/53
Safety Phrases S53-S45-S61
RIDADR UN 2651 6.1/PG 3
WGK Germany 3
RTECS BY5425000
Packaging Group III
Hazard Class 6.1
HS Code 2921590033

 Synthetic Route

 Customs

HS Code 2921590033
Summary 2921590033 4,4'-methylenedianiline。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:13.0%。MFN tarrif:6.5%。general tariff:30.0%

 Articles585

More Articles
Protective effect of Ferula gummosa hydroalcoholic extract against nitric oxide deficiency-induced oxidative stress and inflammation in rats renal tissues.

Clin. Exp. Hypertens. 37(2) , 136-41, (2015)

Nitric oxide (NO) synthase inhibition increases hypertension and causes renal injury. Ferula gummosa is used in Iranian traditional medicine for treatment of several diseases and has been reported to ...
The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages.

Int. J. Nanomedicine 10 , 821-38, (2015)

To investigate the sonoactivity of hypericin (HY), together with its sonodynamic effect on THP-1 macrophages and the underlying mechanism.CCK-8 was used to examine cell viability. Confocal laser scann...
Enhanced antioxidant capacity of dental pulp-derived iPSC-differentiated hepatocytes and liver regeneration by injectable HGF-releasing hydrogel in fulminant hepatic failure.

Cell. Transplant. 24(3) , 541-59, (2015)

Acute hepatic failure (AHF) is a severe liver injury leading to sustained damage and complications. Induced pluripotent stem cells (iPSCs) may be an alternative option for the treatment of AHF. In thi...

 Synonyms

Curithane
bis-p-aminophenylmethane
EINECS 202-974-4
4,4’-Diaminodiphenylmethane
p-Toluidine, α-(p-aminophenyl)-
MDA
bis(4-aminophenyl) methane
HT 972
4,4′-methylenedianiline
Benzenamine, 4,4'-methylenebis-
sumicurem
Tonox
ancaminetl
Di(4-aminophenyl)methane
4,4'-Diaminodiphenylmethane
MFCD00007914
DADPM
Tonox R
Tonox 22
4,4'-methanediyldianiline
4,4'-Methylenedianiline
Top Suppliers:I want be here

Get all suppliers and price by the below link:

4,4′-methylenedianiline suppliers

4,4′-methylenedianiline price

Related Compounds: More...
4,4′-Methylenedianiline-15N2, 13C
2416442-06-1
4,4′-dimethoxybenzhydryl 2-methoxybenzoate
1401963-13-0
4,4′-dinonyl-2,2′-bipyridine
142646-58-0
4,4′-Bis(1,2,2-triphenylvinyl)-1,1′-biphenyl
158605-06-2
4,4′-DIPHENOQUINONE (DQ)
494-72-4
[4,4′-bichroman]-2,2′-dione
22782-70-3
4,4′-dimethoxybenzhydryl 2-nitrobenzoate
1401963-08-3
4,4′-Thiodiphenol
2664-63-3
4,4′-bis[2-(4-hexylsulfanylphenyl)vinyl]-2,2′-bipyridine
1080059-70-6
Chemsrc provides 4,4′-methylenedianiline(CAS#:101-77-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 4,4′-methylenedianiline are included as well.>> amp version: 4,4′-methylenedianiline

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved