HZ-1157
Modify Date: 2025-08-22 15:36:16
HZ-1157 structure
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Common Name | HZ-1157 | ||
|---|---|---|---|---|
| CAS Number | 1009734-33-1 | Molecular Weight | 232.282 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 471.6±53.0 °C at 760 mmHg | |
| Molecular Formula | C12H16N4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 239.0±30.9 °C | |
Use of HZ-1157HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2]. |
| Name | 5-(tert-butoxy)quinazoline-2,4-diamine |
|---|---|
| Synonym | More Synonyms |
| Description | HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2]. |
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| Related Catalog | |
| Target |
IC50: 1.0 μmol/L (HCV NS3/4A protease)[2]. |
| In Vitro | HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others[1][2]. Cell Viability Assay[2]. Cell Line: HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others. Concentration: 0-10 μmol/L. Incubation Time: 72 h. Result: Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 471.6±53.0 °C at 760 mmHg |
| Molecular Formula | C12H16N4O |
| Molecular Weight | 232.282 |
| Flash Point | 239.0±30.9 °C |
| Exact Mass | 232.132416 |
| PSA | 87.05000 |
| LogP | 2.10 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.658 |
| Storage condition | -20℃ |
| 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)- |
| 5-tert-butoxy-2,4-diaminoquinazoline |
| 5-tert-butoxyquinazoline-2,4-diamine |
| HZ-1157 |
| 5-[(2-Methyl-2-propanyl)oxy]-2,4-quinazolinediamine |