1009734-33-1

1009734-33-1 structure

Name: HZ-1157
Chemical Name: 5-(tert-butoxy)quinazoline-2,4-diamine
CAS Number: 1009734-33-1
Molecular Formula: C₁₂H₁₆N₄O
Molecular Weight: 232.282
Catalog: Signaling Pathways Metabolic Enzyme/Protease HCV Protease
Create Date: 2018-12-04 12:36:37
Modify Date: 2024-01-09 07:47:44
HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].

Name	5-(tert-butoxy)quinazoline-2,4-diamine
Synonyms	2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)- 5-tert-butoxy-2,4-diaminoquinazoline 5-tert-butoxyquinazoline-2,4-diamine HZ-1157 5-[(2-Methyl-2-propanyl)oxy]-2,4-quinazolinediamine

Description	HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease Research Areas >> Inflammation/Immunology
Target	IC50: 1.0 μmol/L (HCV NS3/4A protease)[2].
In Vitro	HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others[1][2]. Cell Viability Assay[2]. Cell Line: HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others. Concentration: 0-10 μmol/L. Incubation Time: 72 h. Result: Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L.
References	[1]. Ye Yu, et al. Discovering Novel anti-HCV Compounds With Inhibitory Activities Toward HCV NS3/4A Protease. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. [2]. Bo Chao, et al. Discovery and Optimization of 2,4-diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors. J Med Chem . 2012 Apr 12;55(7):3135-43.