Triclabendazole sulfoxide
Triclabendazole sulfoxide structure
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Common Name | Triclabendazole sulfoxide | ||
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| CAS Number | 100648-13-3 | Molecular Weight | 375.65700 | |
| Density | 1.69 | Boiling Point | 547.6ºC at 760 mmHg | |
| Molecular Formula | C14H9Cl3N2O2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 285ºC | |
Use of Triclabendazole sulfoxideTriclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2]. |
| Name | 6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole |
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| Synonym | More Synonyms |
| Description | Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.69 |
|---|---|
| Boiling Point | 547.6ºC at 760 mmHg |
| Molecular Formula | C14H9Cl3N2O2S |
| Molecular Weight | 375.65700 |
| Flash Point | 285ºC |
| Exact Mass | 373.94500 |
| PSA | 74.19000 |
| LogP | 5.91850 |
| Vapour Pressure | 4.81E-12mmHg at 25°C |
| Index of Refraction | 1.749 |
| Storage condition | 2-8°C |
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~93%
Triclabendazole... CAS#:100648-13-3 |
| Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 22 p. 3129 - 3134 |
| Precursor 1 | |
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| DownStream 0 | |
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Fasciola hepatica: disruption of the vitelline cells in vitro by the sulphoxide metabolite of triclabendazole.
Parasitol. Res. 82(4) , 333-9, (1996) The effects of the active sulphoxide metabolite of the fasciolicide triclabendazole (Fasinex, Ciba-Geigy) on the vitelline cells of Fasciola hepatica were determined in vitro by transmission electron ... |
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Time-course and accumulation of triclabendazole and its metabolites in bile, liver tissues and flukes collected from treated sheep.
Exp. Parasitol. 136 , 14-9, (2014) The flukicidal compound triclabendazole (TCBZ) has a complex metabolic pattern that includes the systemic presence of its sulphoxide (TCBZ.SO) and sulphone (TCBZ.SO2) metabolites, usually recovered fr... |
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Fasciola gigantica: tegumental surface alterations following treatment in vitro with the sulphoxide metabolite of triclabendazole.
Parasitol. Res. 88(4) , 315-25, (2002) The effect of the active sulphoxide metabolite of the fasciolicide triclabendazole on the surface morphology of the tropical liver fluke, Fasciola gigantica, was determined in vitro by scanning electr... |
| Tcbz-SX |
| Triclabendazole sulfoxide |
| 1H-Benzimidazole,6-chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl) |
| 5-chloro-6-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole |
| triclabendazole sulphoxide |