HE 3286 structure
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Common Name | HE 3286 | ||
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CAS Number | 1001100-69-1 | Molecular Weight | 330.46 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C21H30O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of HE 3286HE3286, a synthetic derivative of the adrenal steroid β-AET, is an orally-active partially NF-κB inhibitor [1][2]. |
Name | 17α-ethynylandrost-5-ene-3β,7β,17β-triol |
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Synonym | More Synonyms |
Description | HE3286, a synthetic derivative of the adrenal steroid β-AET, is an orally-active partially NF-κB inhibitor [1][2]. |
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Related Catalog | |
In Vitro | HE3286 attenuates NF-κB phosphorylation, but not influences IκB phosphorylation of LPS-induces (100 ng/ml; 0-2 hours) murine macrophages [3]. HE3286 (100 nM, overnight) partially, but significantly, blocks the activation of IKK, JNK, p38, and ERK of LPS-induces (100 ng/ml; 0-2 hours) murine macrophages[3]. Western Blot Analysis[3] Cell Line: LPS-induced murine macrophages Concentration: 100 nM Incubation Time: overnight Result: Attenuated NF-κB phosphorylation. Blocked the activation of IKK, JNK, p38, and ERK partially, but significantly. |
In Vivo | HE3286 (80 mg/kg; 0-24h) freely penetrates the BBB in male CD-1 mice[4]. HE3286 (40 mg/kg; gavage; twice-daily for 4 days) increases the numbers of tyrosine hydroxylase-positive cells and decreases the numbers of damaged neurons in PD mice [4]. HE3286 (40 mg/kg; intraperitoneal injection; daily for 40 days) suppresses inflammation, reduces demyelination and axonal loss, and promotes RGC survival during experimental optic neuritis of EAE mice [2]. HE3286 (25-50 mg/kg; oral gavage; daily for 22-49 days) reduces joint inflammation, synovial proliferation, and erosion of DBA/1 Lac male CIA mice [1]. |
References |
Molecular Formula | C21H30O3 |
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Molecular Weight | 330.46 |
Exact Mass | 330.21900 |
PSA | 60.69000 |
LogP | 2.64520 |
17α-ethynyl-5-androstene-3β,7β,17β-triol |
17α-ethynyl-androst-5-ene-3β,7β,17β-triol |
HE 3286 |