Crolibulin

Modify Date: 2025-08-26 13:32:45

Use of Crolibulin

Crolibulin is a small molecule tubulin polymerization inhibitor.

Name	(4R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile
Synonym	More Synonyms

Description	Crolibulin is a small molecule tubulin polymerization inhibitor.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Cancer
Target	tubulin polymerization[1]
References	[1]. Kalmuk J, et al. Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer. Oncotarget. 2015 Sep 15;6(27):24376-92. [2]. Zhai X, et al. Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site. Sci Rep. 2017 Feb 27;7:43398.

Molecular Formula	C₁₈H₁₇BrN₄O₃
Molecular Weight	417.25700
Exact Mass	416.04800
PSA	129.54000
LogP	4.71158
InChIKey	JXONINOYTKKXQQ-CQSZACIVSA-N
SMILES	COc1cc(C2C(C#N)=C(N)Oc3c2ccc(N)c3N)cc(Br)c1OC
Storage condition	2-8℃

Crolibulin

(R)-2,7,8-triamino-3-cyano-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene

Crolibulin [USAN:INN]

Crolibulin [USAN]

R(-)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromene

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Price: $496/10mM*1mLinDMSO

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