1000852-17-4

1000852-17-4 structure

Name: Crolibulin
Chemical Name: (4R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile
CAS Number: 1000852-17-4
Molecular Formula: C₁₈H₁₇BrN₄O₃
Molecular Weight: 417.25700
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2016-08-30 04:14:23
Modify Date: 2025-08-26 13:32:45
Crolibulin is a small molecule tubulin polymerization inhibitor.

Name	(4R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile
Synonyms	Crolibulin (R)-2,7,8-triamino-3-cyano-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene Crolibulin [USAN:INN] Crolibulin [USAN] R(-)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromene

Description	Crolibulin is a small molecule tubulin polymerization inhibitor.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Cancer
Target	tubulin polymerization[1]
References	[1]. Kalmuk J, et al. Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer. Oncotarget. 2015 Sep 15;6(27):24376-92. [2]. Zhai X, et al. Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site. Sci Rep. 2017 Feb 27;7:43398.