211735-76-1
211735-76-1 structure
- Name: farampator
- Chemical Name: 2,1,3-benzoxadiazol-5-yl(piperidin-1-yl)methanone
- CAS Number: 211735-76-1
- Molecular Formula: C12H13N3O2
- Molecular Weight: 231.251
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2017-06-25 16:18:55
- Modify Date: 2024-01-09 08:21:14
-
Farampator (CX-691;Org24448) is an AMPA receptor positive modulator.
| Name | 2,1,3-benzoxadiazol-5-yl(piperidin-1-yl)methanone |
|---|---|
| Synonyms |
Methanone, 2,1,3-benzoxadiazol-5-yl-1-piperidinyl-
2,1,3-Benzoxadiazol-5-yl(1-piperidinyl)methanone 1-(benzofurazan-5-ylcarbonyl)piperidine CX-691 UNII-7X6P5N8K2L Farampator |
| Description | Farampator (CX-691;Org24448) is an AMPA receptor positive modulator. |
|---|---|
| Related Catalog | |
| In Vivo | Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia. CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.)[1]. Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Furthermore, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs[2]. |
| Animal Admin | Rats: Rats are dosed acutely with CX691 (0.1, 0.3 and 1.0; 2 ml/kg; p.o.) or vehicle (1% methylcellulose; 1 ml/kg; p.o.), and microdialysate samples are collected every 30 min for 4 h post dose. At the end of each experimental day, animals are returned to their home cage and re-used in a randomised cross-over design, allowing at least 7 days drug ishout before subsequent use. After the completion of the final microdialysis experiment, animals are killed, and brains are removed and stored in formalin solution for probe placement verification[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 398.3±34.0 °C at 760 mmHg |
| Molecular Formula | C12H13N3O2 |
| Molecular Weight | 231.251 |
| Flash Point | 194.7±25.7 °C |
| Exact Mass | 231.100784 |
| PSA | 59.23000 |
| LogP | 0.91 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.621 |
| Storage condition | 2-8℃ |