Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Etravirine (TMC125)
Price: ￥238.0/5mg ￥738.0/25mg
Purity: 95.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Etravirine
Price: $400.0/100mg $800.0/250mg $1600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Etravirine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: etravirine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

269055-15-4

269055-15-4 structure

269055-15-4 structure

Name: Etravirine (TMC125)
Chemical Name: etravirine
CAS Number: 269055-15-4
Molecular Formula: C₂₀H₁₅BrN₆O
Molecular Weight: 435.277
Catalog: Biochemical Inhibitor Microbiology Reverse Transcriptase inhibitor
Create Date: 2018-07-01 11:08:11
Modify Date: 2024-01-03 08:11:25
Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Name	etravirine
Synonyms	Benzonitrile, 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl- etravirine 4-({6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl}oxy)-3,5-dimethylbenzonitrile tmc 125

Description	Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection
In Vitro	TMC125 is highly active against wild-type HIV-1 (50% effective concentration [EC50]=1.4 to 4.8 nM) and shows some activity against HIV-2 (EC50=3.5 μM). TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus. TMC125 has activity for 19 viruses with EC50 of < 5 nM[1].
In Vivo	Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group[2].
References	[1]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468 [2]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48.

Density	1.6±0.1 g/cm3
Boiling Point	637.4±65.0 °C at 760 mmHg
Melting Point	265ºC (dec.)
Molecular Formula	C₂₀H₁₅BrN₆O
Molecular Weight	435.277
Flash Point	339.3±34.3 °C
Exact Mass	434.049072
PSA	120.64000
LogP	4.19
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.703
Storage condition	-20°C Freezer

Hazard Codes	Xi