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52936-64-8

52936-64-8 structure
52936-64-8 structure
  • Name: Caulophyllogenin
  • Chemical Name: (4aR,5R,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-5,10-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
  • CAS Number: 52936-64-8
  • Molecular Formula: C30H48O5
  • Molecular Weight: 488.69900
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
  • Create Date: 2018-02-06 08:00:00
  • Modify Date: 2025-08-25 10:23:13
  • Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC50 of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation[1][2].
Name (4aR,5R,6aR,6aS,6bR,8aR,9R,10S,12aR,14bS)-5,10-dihydroxy-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Synonyms Caulophyllogenin
EINECS 258-265-5
Description Caulophyllogenin is a triterpene saponin extracted from M. polimorpha. Caulophyllogenin is a partial PPARγ agonist, with an EC50 of 12.6 μM. Caulophyllogenin can be used for the research of type-2 diabetes, obesity, metabolic syndrome and inflammation[1][2].
Related Catalog
Target

PPARγ:12.6 μM (EC50)

References

[1]. Montanari R, et, al. Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin. Sci Rep. 2016 Jun 10; 6:27658.

[2]. Zhang Y, et, al. Studies on cytotoxic triterpene saponins from the leaves of Aralia elata. Food Chem. 2013 May 1;138(1):208-13.
Density 1.19g/cm3
Boiling Point 621.5ºC at 760mmHg
Melting Point >300ºC (dec.)
Molecular Formula C30H48O5
Molecular Weight 488.69900
Flash Point 343.7ºC
Exact Mass 488.35000
PSA 97.99000
LogP 5.17680
Index of Refraction 1.58
Storage condition 2-8°C
631-01-6 structure

631-01-6

~%

52936-64-8 structure

52936-64-8

Literature: Rodriguez-Diaz, Maite; Delporte, Carla; Cartagena, Carlos; Cassels, Bruce K.; Gonzalez, Patricia; Silva, Ximena; Leon, Fredy; Wessjohann, Ludger A. Journal of Pharmacy and Pharmacology, 2011 , vol. 63, # 5 p. 718 - 724
1154058-37-3 structure

1154058-37-3

~%

5328-37-0 structure

5328-37-0

50-99-7 structure

50-99-7

52936-64-8 structure

52936-64-8

Literature: Matsuo, Yukiko; Watanabe, Kazuki; Mimaki, Yoshihiro Journal of Natural Products, 2009 , vol. 72, # 6 p. 1155 - 1160
1154058-34-0 structure

1154058-34-0

~%

5328-37-0 structure

5328-37-0

50-99-7 structure

50-99-7

52936-64-8 structure

52936-64-8

Literature: Matsuo, Yukiko; Watanabe, Kazuki; Mimaki, Yoshihiro Journal of Natural Products, 2009 , vol. 72, # 6 p. 1155 - 1160
1431883-08-7 structure

1431883-08-7

~%

50-99-7 structure

50-99-7

52936-64-8 structure

52936-64-8

Literature: Chemistry and Biodiversity, , vol. 10, # 4 p. 703 - 710
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