95933-74-7

95933-74-7 structure

Name: Trimidox
Chemical Name: 4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one
CAS Number: 95933-74-7
Molecular Formula: C₇H₈N₂O₄
Molecular Weight: 184.15
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2017-09-20 03:21:45
Modify Date: 2024-01-10 14:08:39
Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC50 of 35 μM[1].

Name	4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one
Synonyms	2,5-Cyclohexadien-1-one, 4-[amino(hydroxyamino)methylene]-2,6-dihydroxy- Trimidox Benzenecarboximidamide,N,3,4,5-tetrahydroxy N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE 4-[Amino(hydroxyamino)methylene]-2,6-dihydroxy-2,5-cyclohexadien-1-one Benzenecarboximidamide, N,3,4,5-tetrahydroxy- 3,4,5-Trihydroxybenzamidoxime N,3,4,5-Tetrahydroxybenzenecarboximidamide

Description	Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC50 of 35 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
References	[1]. T Szekeres, et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood. 1994 Dec 15;84(12):4316-21.