25577-04-2
25577-04-2 structure
- Name: 1,6,7-Trihydroxy-9H-xanthen-9-one
- Chemical Name: 1,6,7-trihydroxyxanthen-9-one
- CAS Number: 25577-04-2
- Molecular Formula: C13H8O5
- Molecular Weight: 244.20
- Catalog: Natural product Xanthone
- Create Date: 2018-06-17 17:36:28
- Modify Date: 2025-08-25 20:54:58
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1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1].
| Name | 1,6,7-trihydroxyxanthen-9-one |
|---|---|
| Synonyms |
9H-Xanthen-9-one, 1,6,7-trihydroxy-
1,6,7-Trihydroxy-xanthon 1,6,7-Trihydroxy-xanthen-9-on 1,6,7-trihydroxy-xanthen-9-one W2665 1,6,7-Trihydroxy-9H-xanthen-9-one 1,6,7-Trihydroxyxanthone |
| Description | 1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 1,6,7-Trihydroxyxanthone (0-10 µg/mL; 0-72 h) 抑制 HepG2、Bel7404 细胞的细胞增殖[1]。 1,6,7-Trihydroxyxanthone (5 µg/mL; 72 h) 诱导 HepG2 细胞凋亡[1]. 1,6,7-Trihydroxyxanthone 降低 Bmi-1 表达并增加 P14、P16 的蛋白表达水平[1]。 1,6,7-Trihydroxyxanthone 在 HepG2、Bel7404 细胞中诱导 MiR-218 上调[1]。 Cell Proliferation Assay[1] Cell Line: HepG2, Bel7404 cells Concentration: 0, 1.25, 2.5, 5, 10 µg/mL Incubation Time: 0, 24, 48, 72 h Result: Inhibited cell proliferation of HepG2 and Bel7404 in a time- and dose-dependent manner. Apoptosis Analysis[1] Cell Line: HepG2 cells Concentration: 5 μg/ml Incubation Time: 72 h Result: Induced cell apoptosis. Western Blot Analysis[1] Cell Line: HepG2, Bel7404 cells Concentration: Incubation Time: Result: Suppressed Bmi-1 expressio and increased the expression of P14, P16 protein levels. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 509.2±50.0 °C at 760 mmHg |
| Molecular Formula | C13H8O5 |
| Molecular Weight | 244.20 |
| Flash Point | 204.8±23.6 °C |
| Exact Mass | 244.037170 |
| PSA | 90.90000 |
| LogP | 1.50 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.758 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2932999099 |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |