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372-09-8

372-09-8 structure
372-09-8 structure

Name cyanoacetic acid
Synonyms EINECS 206-743-9
Acetic acid, 2-cyano-
Cyanoacetic acid
Cyano-acetic acid
MFCD00002677
Density 1.3±0.1 g/cm3
Boiling Point 318.5±0.0 °C at 760 mmHg
Melting Point 65 °C
Molecular Formula C3H3NO2
Molecular Weight 85.061
Flash Point 107.8±0.0 °C
Exact Mass 85.016380
PSA 61.09000
LogP -0.76
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.440
Water Solubility 1000 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AG3675000
CHEMICAL NAME :
Acetic acid, cyano-
CAS REGISTRY NUMBER :
372-09-8
BEILSTEIN REFERENCE NO. :
0506325
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C3-H3-N-O2
MOLECULAR WEIGHT :
85.07
WISWESSER LINE NOTATION :
QV1CN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Skin and Appendages - hair
REFERENCE :
LONZA# Personal Communication from LONZA Ltd., CH-4002, Basel, Switzerland Volume(issue)/page/year: 12JAN1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1900 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 5,161,1899
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 5,161,1899 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4050 No. of Facilities: 17 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 919 (estimated) No. of Female Employees: 306 (estimated)
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302 + H332-H314
Supplemental HS Contact with acids liberates toxic gas.
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C:Corrosive
Risk Phrases R20/22;R31;R34;R52/53
Safety Phrases S26-S36/37/39-S45-S61-S20
RIDADR UN 3261 8/PG 2
WGK Germany 2
RTECS AG3675000
Packaging Group II
Hazard Class 8
HS Code 2926909090
HS Code 2926909090
Summary HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%