1217733-17-9

1217733-17-9 structure

Name: L-Epinephrine-d3
Chemical Name: 4-[(1R)-1-hydroxy-2-(trideuteriomethylamino)ethyl]benzene-1,2-diol
CAS Number: 1217733-17-9
Molecular Formula: C₉H₁₀D₃NO₃
Molecular Weight: 186.22
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2017-01-03 15:55:48
Modify Date: 2024-01-08 17:54:11
L-Epinephrine-d3 is deuterium labeled L-Epinephrine. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.

Name	4-[(1R)-1-hydroxy-2-(trideuteriomethylamino)ethyl]benzene-1,2-diol
Synonyms	Adrenaline-d3 Renoform-d3 Adrenalin-d3 [2H3]-Adrenaline Levoepinephrine-d3 Renostypticin-d3 L-(-)-Epinephrine-d3 Adnephrine-d3 Adrenal-d3

Description	L-Epinephrine-d3 is deuterium labeled L-Epinephrine. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Alm A, et al. The effect of topical l-epinephrine on regional ocular blood flow in monkeys. Invest Ophthalmol Vis Sci. 1980 May;19(5):487-91. [3]. Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44. [4]. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments. Exp Gerontol. 2013 Feb;48(2):115-27. [5]. Callaway CW, et al. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42.