21446-35-5
21446-35-5 structure
- Name: guatteguamerine
- Chemical Name: guattegaumerine
- CAS Number: 21446-35-5
- Molecular Formula: C36H40N2O6
- Molecular Weight: 596.71300
- Catalog: Research Areas Neurological Disease
- Create Date: 2016-11-22 02:29:01
- Modify Date: 2024-01-14 05:04:42
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Guattegaumerine is a bisbenzylisoquinoline alkaloid with antimitotic, cytotoxic and neuroprotective activities[1].
| Name | guattegaumerine |
|---|---|
| Synonyms |
7-Isoquinolinol,1,2,3,4-tetrahydro-1-((4-(2-hydroxy-5-((1,2,3,4-tetrahydro-7-hydroxy-6-methoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)phenyl)methyl)-6-methoxy-2-methyl-,(R-(R*,R*))
Guatteguamerine (1R)-1-[4-(2-hydroxy-5-{[(1R)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}phenoxy)benzyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol Dauriciline (1R)-1-[[4-[2-hydroxy-5-[[(1R)-7-hydroxy-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol N,N'-Dimethyllindoldhamine Guattegaumerine 7,7'-Demethyldauricine |
| Description | Guattegaumerine is a bisbenzylisoquinoline alkaloid with antimitotic, cytotoxic and neuroprotective activities[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Guattegaumerine (1.25-6.25 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) significantly increases cell viability at 1.25 and 2.5μM; and guattegaumerine pretreatment significantly inhibits LDH efflux[1]. Guattegaumerine (2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) markedly reduces the oxidative stress-induced apoptosis in rat cortical neurons when compares with the control group[1]. Guattegaumerine (1.25-2.5 μM; 24 hours; 30 min before exposure to serum-starvation+H2O2) decreases H2O2 and KCl induced Ca[2+]i increase in cortical neurons[1]. |
| References |
| Molecular Formula | C36H40N2O6 |
|---|---|
| Molecular Weight | 596.71300 |
| Exact Mass | 596.28900 |
| PSA | 94.86000 |
| LogP | 6.03210 |
| Vapour Pressure | 1.54E-22mmHg at 25°C |
| Hazard Codes | Xi |
|---|