178249-42-8

178249-42-8 structure

Name: Nociceptin(1-7)(Orphanin FQ(1-7))
Chemical Name: (2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoic acid
CAS Number: 178249-42-8
Molecular Formula: C₃₁H₄₁N₇O₉
Molecular Weight: 655.69900
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2016-10-09 18:19:17
Modify Date: 2024-01-10 08:33:34
Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1].

Name	(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoic acid
Synonyms	TCS JNK 6o L-Alanine,L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl

Description	Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1 (NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
In Vivo	Nociceptin (1-7) (intrathecal injection; 150–1200 nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1–7) is injected simultaneously with nociceptin (3.0 fmol), nociceptin-induced hyperalgesia is significantly reduced[1]. Animal Model: Mice[1] Dosage: 150–1200 nmol Administration: Intrathecal injection; single dose Result: Co-treatment with nociceptin could reduce hyperalgesia.
References	[1]. T Sakurada, et al. Nociceptin (1 - 7) antagonizes nociceptin-induced hyperalgesia in mice.Br J Pharmacol. 1999 Nov;128(5):941-4.