1350965-83-1
1350965-83-1 structure
- Name: CGS-12066 maleate
- Chemical Name: (E)-but-2-enedioic acid,4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline
- CAS Number: 1350965-83-1
- Molecular Formula: C21H21F3N4O4
- Molecular Weight: 450.41
- Create Date: 2017-08-08 05:19:03
- Modify Date: 2025-09-30 15:28:34
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CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT1A , 5-HT1B ,5-HT1C and 5-HT1D with pEC50 values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease[1].
| Name | (E)-but-2-enedioic acid,4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline |
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| Synonyms | 7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo-[1,2-a]quinoxaline maleate salt |
| Description | CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT1A , 5-HT1B ,5-HT1C and 5-HT1D with pEC50 values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease[1]. |
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| Related Catalog | |
| Target |
pEC50: 6.41 (5-HT1A), 7.56 (5-HT1B), 4.05 (5-HT1C) and 7.11 (5-HT1D)[1]. pKD: 7.19 (5-HT1A), 6.94 (5-HT1B), 4.89 (5-HT1C) and 7.49 (5-HT1D)[1]. |
| In Vitro | CGS-12066 (maleate) 对 5-HT1A、5-HT1B、5-HT1C 和 5-HT1D 具有激动作用，pEC50 值分别为 6.41、7.56、4.05 和 7.11[1]。 CGS-12066 (maleate) 对 5-HT1A、5-HT1B、5-HT1C和5-HT1D具有激动作用，pKD 值分别为 7.19、6.94、4.89 和 7.49[1]。 CGS-12066 (maleate) 以低效能刺激肌醇磷酸盐的积累[1]。 CGS-12066 (maleate) 作为部分激动剂抑制小腿黑质毛喉素刺激的腺苷酸环化酶活性[1]。 |
| References |
| Molecular Formula | C21H21F3N4O4 |
|---|---|
| Molecular Weight | 450.41 |
| Exact Mass | 450.15100 |
| PSA | 98.38000 |
| LogP | 2.97280 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |