1350965-83-1

1350965-83-1 structure

Name: CGS-12066 maleate
Chemical Name: (E)-but-2-enedioic acid,4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline
CAS Number: 1350965-83-1
Molecular Formula: C₂₁H₂₁F₃N₄O₄
Molecular Weight: 450.41
Create Date: 2017-08-08 05:19:03
Modify Date: 2024-04-03 21:28:59
CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT1A , 5-HT1B ,5-HT1C and 5-HT1D with pEC50 values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease[1].

Name	(E)-but-2-enedioic acid,4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline
Synonyms	7-Trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrrolo-[1,2-a]quinoxaline maleate salt

Description	CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT1A , 5-HT1B ,5-HT1C and 5-HT1D with pEC50 values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	pEC50: 6.41 (5-HT1A), 7.56 (5-HT1B), 4.05 (5-HT1C) and 7.11 (5-HT1D)[1]. pKD: 7.19 (5-HT1A), 6.94 (5-HT1B), 4.89 (5-HT1C) and 7.49 (5-HT1D)[1].
In Vitro	CGS-12066 (maleate) 对 5-HT1A、5-HT1B、5-HT1C 和 5-HT1D 具有激动作用，pEC50 值分别为 6.41、7.56、4.05 和 7.11[1]。 CGS-12066 (maleate) 对 5-HT1A、5-HT1B、5-HT1C和5-HT1D具有激动作用，pKD 值分别为 7.19、6.94、4.89 和 7.49[1]。 CGS-12066 (maleate) 以低效能刺激肌醇磷酸盐的积累[1]。 CGS-12066 (maleate) 作为部分激动剂抑制小腿黑质毛喉素刺激的腺苷酸环化酶活性[1]。
References	[1]. Schoeffter P,et al. Interaction of arylpiperazines with 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors: do discriminatory 5-HT1B receptor ligands exist?. Naunyn Schmiedebergs Arch Pharmacol. 1989;339(6):675-683.

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