23930-37-2

23930-37-2 structure

Name: 3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate
Chemical Name: (3α,5α)-3-Hydroxy-11,20-dioxopregnan-21-yl acetate
CAS Number: 23930-37-2
Molecular Formula: C₂₃H₃₄O₅
Molecular Weight: 390.51300
Catalog: Research Areas Neurological Disease
Create Date: 2017-04-10 06:44:14
Modify Date: 2024-01-09 21:28:48
Alphadolone acetate (Alfadolone acetate) is a steroid anaesthetic, with antinociception[1].

Name	(3α,5α)-3-Hydroxy-11,20-dioxopregnan-21-yl acetate
Synonyms	2-phenoxyethyl 4-(2,3-dimethoxyphenyl)-7-(4-methoxyphenyl)-2-methyl-5-oxo-1,4,6,7,8-pentahydroquinoline-3-carboxylate 2-phenoxyethyl 4-(2,3-dimethoxyphenyl)-7-(4-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate endo-Bicyclo<3.3.1>nonan-3-ol exo-Bicyclo<3.3.1>nonanol-3 exo-Bicyclo<3.3.1>nonan-3-ol

Description	Alphadolone acetate (Alfadolone acetate) is a steroid anaesthetic, with antinociception[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	Alphadolone acetate (anaesthetized with a 3:1 mixture of Alphaxalone and Alphadolone acetate; i.m.) blocks the oestrogen-stimulated luteinizing hormone (LH) surge and impairs pulsatile secretion in female rats, when combined with alphaxalonet[2]. Alphadolone acetate (14 mL/kg; i.p.; single dosage) decreases serum concentrations of LH in castrated rats[3]. Animal Model: Inbred Wistar-derived colony female rats (intramuscularly injected with 20 µg/100g oestradiol benzoate)[2] Dosage: Anaesthetized with a 3 :1 mixture of Alphaxalone and Alphadolone acetate Administration: i.m. Result: Blocked the oestrogen-stimulated LH surge and impairs pulsatile secretion. Animal Model: Male Sprague-Dawley rats (orchidectomized; aged 90-120 days and weighing 300-350 g)[3] Dosage: 14 mL/kg Administration: i.p.; single dosage Result: Decreased serum concentrations of LH.