1021868-92-7

1021868-92-7 structure

Name: ZM 39923 HCl
Chemical Name: N-benzyl-N-isopropyl-3-(2-naphthyl)but-3-en-1-amine,hydrochloride
CAS Number: 1021868-92-7
Molecular Formula: C₂₃H₂₆ClNO
Molecular Weight: 367.91
Catalog: Biochemical Inhibitor Tyrosine protein kinase/signal transducer and transcriptional activator inhibitor (JAK/STAT) JAK inhibitor
Create Date: 2018-10-11 23:51:42
Modify Date: 2024-01-02 09:17:48
ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.

Name	N-benzyl-N-isopropyl-3-(2-naphthyl)but-3-en-1-amine,hydrochloride
Synonyms	2-Naphthalenepropanamine, γ-methylene-N-(1-methylethyl)-N-(phenylmethyl)-, hydrochloride (1:1) N-Benzyl-N-isopropyl-3-(2-naphthyl)-3-buten-1-amine hydrochloride (1:1) 3-[(1-Methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone hydrochloride ZM 39923 hydrochloride ZM39923 (hydrochloride)

Description	ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease
Target	JAK3:7.1 (pIC50) JAK1:4.4 (pIC50) EGF-R:5.6 (pIC50) Lck:5.0 (pIC50) CDK4:5.0 (pIC50) TGM2:10 nM (IC50)
In Vitro	ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC50, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1]. ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca2+ activated form of TGM2[2]. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells[3].
Cell Assay	PCI-37B (a metastatic SCCHN cell line expressing CCR7) cells are cultured in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum, penicillin, and streptomycin in an atmosphere of 5% CO2 and 95% air at 37°C. The ZM39923 inhibitor treatment at the dose determined using the Cell Counting Kit-8[3].
References	[1]. Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. [2]. Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. [3]. Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197.

Molecular Formula	C₂₃H₂₆ClNO
Molecular Weight	367.91
PSA	3.24000
LogP	6.95570
Storage condition	-20°C

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