Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID
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Purity: 98.0%
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766536-21-4

766536-21-4 structure

Name: PF 356231
Chemical Name: (3R)-3-Phenyl-3-[({4-[4-(4-pyridinyl)phenyl]-2-thienyl}carbonyl)a mino]propanoic acid
CAS Number: 766536-21-4
Molecular Formula: C₂₅H₂₀N₂O₃S
Molecular Weight: 428.50
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2016-12-07 21:20:45
Modify Date: 2025-09-15 19:12:48
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].

Name	(3R)-3-Phenyl-3-[({4-[4-(4-pyridinyl)phenyl]-2-thienyl}carbonyl)a mino]propanoic acid

Description	PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
References	[1]. Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76.