65528-98-5

65528-98-5 structure

Name: 1-Oleoyl lysophosphatidic acid
Chemical Name: [(2R)-2-hydroxy-3-phosphonooxypropyl] octadec-9-enoate
CAS Number: 65528-98-5
Molecular Formula: C₂₁H₄₁O₇P
Molecular Weight: 436.520
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2016-12-19 07:06:47
Modify Date: 2024-01-21 09:07:00
1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation[1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity[2].

Name	[(2R)-2-hydroxy-3-phosphonooxypropyl] octadec-9-enoate
Synonyms	9-Octadecenoic acid, (2R)-2-hydroxy-3-(phosphonooxy)propyl ester, (9Z)- (2R)-2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate (2R)-2-Hydroxy-3-(phosphonooxy)propyl (9Z)-9-octadecenoate

Description	1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) is an abundant lysophosphatidic acid (LPA) species with high biological activity due to its strong affinity for the LPA receptors. 1-Oleoyl lysophosphatidic acid is commonly used in most laboratories as a reagent for LPA receptor activation[1]. 1-Oleoyl lysophosphatidic acid increases SRE-driven β-galactosidase activity[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Neurological Disease
In Vivo	1-Oleoyl lysophosphatidic acid (1-Oleoyl-sn-glycero-3-phosphate) (0.4-2 μg; i.c.v.; 9-week-old male Wistar rats) induces anxiety-like responses in the elevated plus maze (EPM) under novelty conditions[1]. Animal Model: 9-week-old male Wistar rats[1] Dosage: 0.4-2 μg Administration: I.c.v. Result: Reduced open arm exploration under novelty conditions and had no effect under habituated conditions in the EPM.
References	[1]. Castilla-Ortega E, et al. 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats. PLoS One. 2014;9(1):e85348. Published 2014 Jan 7. [2]. Perkins LM, et al. Activation of serum response element-regulated genes by lysophosphatidic acid. Nucleic Acids Res. 1994;22(3):450-452.