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42438-89-1

42438-89-1 structure
42438-89-1 structure
  • Name: Pinostilbene
  • Chemical Name: 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxyphenol
  • CAS Number: 42438-89-1
  • Molecular Formula: C15H14O3
  • Molecular Weight: 242.270
  • Catalog: Natural product Phenols
  • Create Date: 2018-08-30 16:07:19
  • Modify Date: 2025-08-26 11:13:10
  • Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells[1].
Name 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxyphenol
Synonyms mono-methylated resveratrol
3,4'-Dihydroxy-5-methoxy-trans-stilbene
3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol
Pinostilbene
Pinostilbene hydrate
3-methoxyresveratrol
trans-3,4'-dihydroxy-5-methoxystilbene
phenol (3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy
5,4'-dihydroxy-3-methoxystilbene
trans-Pinostilbene
3-methoxy-4',5-dihydroxy-trans-stilbene
4,3'-dihydroxy-5'-methoxystilbene
Phenol, 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-
Description Pinostilbene is a major metabolite of Pterostilbene. Pinostilbene exhibits inhibitory effects on colon cancer cells[1].
Related Catalog
In Vitro Pinostilbene (0- 40 μM; 24 hours, 48 hours) does not cause significant inhibition on the growth of normal colon cells[1]. Pinostilbene (20 μM, 40 μM; 24 hours, 48 hours) causes a significant and dose-dependent increase in the percentage of cells in S phase in both HCT116 and HT29 cells compared to the control cells[1]. Pinostilbene at μM also induces a modest increase of cell population in G2/M phase in HT29 cells[1]. Pinostilbene(20 μM, 40 μM; 24 hours, 48 hours) modulates expression of key signaling proteins related to cell proliferation and apoptosis[1]. Pinostilbene also acts as a resveratrol methylated derivative and displays protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells[2]. Cell Viability Assay[1] Cell Line: HCT116 cells, HT29 cells Concentration: 24 hours, 48 hours Incubation Time: 0-100 μM Result: Inhibited the growth of two human colon cancer cells. Apoptosis Analysis[1] Cell Line: HCT116 cells, HT29 cells Concentration: 20 μM, 40 μM Incubation Time: 24 hours, 48 hours Result: Caused a significant and dose-dependent increase in the percentage of cells in S phase. Cell Viability Assay[1] Cell Line: HCT116 cells Concentration: 20 μM,40 μM Incubation Time: 24 hours, 48 hours Result: Significantly increased the expression levels of p53, Bax, cleaved caspase-3, cleaved PARP and p21Cip1/Waf1, while decreased the expression levels of cyclin E and p-Rb.
References

[1]. Sun Y, et al. Identification of pinostilbene as a major colonic metabolite of pterostilbene and its inhibitory effects on colon cancer cells. Mol Nutr Food Res. 2016 Sep;60(9):1924-32.

[2]. Chao J, et al. Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J Nutr Biochem. 2010 Jun;21(6):482-9.
Density 1.3±0.1 g/cm3
Boiling Point 454.3±33.0 °C at 760 mmHg
Melting Point 117-118℃
Molecular Formula C15H14O3
Molecular Weight 242.270
Flash Point 228.5±25.4 °C
Exact Mass 242.094299
PSA 49.69000
LogP 3.80
Appearance white to tan
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.692
Storage condition 2-8°C
Water Solubility DMSO: ≥13mg/mL
Hazard Codes Xi,N
Risk Phrases 37/38-41-50
Safety Phrases 26-39-61
RIDADR UN 3077 9 / PGIII
HS Code 2909500000
537-42-8 structure

537-42-8

~%

42438-89-1 structure

42438-89-1

Literature: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE; MIZUNO, Cassia, Suemi Patent: WO2008/70872 A1, 2008 ; Location in patent: Page/Page column 28-29 ;
185249-89-2 structure

185249-89-2

~%

42438-89-1 structure

42438-89-1

Literature: Polunin, Konstantin E.; Polunina, Irina A.; Schmalz, Hans-Guenther Mendeleev Communications, 2002 , vol. 12, # 5 p. 178 - 180
Precursor  1

DownStream  1

HS Code 2909500000
Summary 2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
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