93-29-8

93-29-8 structure

Name: Acetylisoeugenol
Chemical Name: 1-Acetoxy-2-methoxy-4-(1-propenyl)benzene
CAS Number: 93-29-8
Molecular Formula: C₁₂H₁₄O₃
Molecular Weight: 206.238
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-02-10 08:00:00
Modify Date: 2024-01-08 12:06:36
Isoeugenol acetate, an essential oil constituent of nutmeg, clove, and cinnamon, shows excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enzymes (IC50=77 nM; Ki=16 nM), α-glycosidase (IC50=19.25 nM; Ki=21 nM), and α-amylase (IC50=411.5 nM). Isoeugenol acetate is used medical and cosmetics industries for its antioxidant, anticancer, antimicrobial and anti-inflammatory properties[1][2].

Name	1-Acetoxy-2-methoxy-4-(1-propenyl)benzene
Synonyms	2-Methoxy-4-[(1E)-1-propenyl]phenyl acetate EINECS 202-236-1 2-Methoxy-4-[(1E)-prop-1-en-1-yl]phenyl acetate Phenol, 2-methoxy-4-[(1E)-1-propen-1-yl]-, acetate MFCD00026984 2-Methoxy-4-[(1E)-1-propen-1-yl]phenylacetat 2-Methoxy-4-[(1E)-1-propen-1-yl]phenyl acetate Phenol, 2-methoxy-4-(1-propenyl)-, acetate, (E)- Acétate de 2-méthoxy-4-[(1E)-1-propèn-1-yl]phényle 1-acetoxy-2-methoxy-4-(1-propenyl)benzene

Description	Isoeugenol acetate, an essential oil constituent of nutmeg, clove, and cinnamon, shows excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enzymes (IC50=77 nM; Ki=16 nM), α-glycosidase (IC50=19.25 nM; Ki=21 nM), and α-amylase (IC50=411.5 nM). Isoeugenol acetate is used medical and cosmetics industries for its antioxidant, anticancer, antimicrobial and anti-inflammatory properties[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 77 nM (AChE), 19.25 nM (α-glycosidase), 411.5 nM (α-amylase)[1] Ki: 16 nM (AChE), 21 nM (α-glycosidase)[1]
References	[1]. Fevzi Topal.Anticholinergic and antidiabetic effects of isoeugenol from clove (Eugenia caryophylata) oil. International Journal of Food Properties, 22:1,583-592. [2]. Hyldgaard M, et al. Isoeugenol has a non-disruptive detergent-like mechanism of action. Front Microbiol. 2015 Jul 28;6:754.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,819,1975

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,819,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83234 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 394 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83234 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	SL7940000