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60668-24-8

60668-24-8 structure
60668-24-8 structure
  • Name: Alafosfalin
  • Chemical Name: (s)-alanyl-(r)-1-aminoethylphosphonic acid
  • CAS Number: 60668-24-8
  • Molecular Formula: C5H13N2O4P
  • Molecular Weight: 196.14100
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2018-10-04 14:52:25
  • Modify Date: 2025-08-25 17:22:47
  • Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties[1].
Name (s)-alanyl-(r)-1-aminoethylphosphonic acid
Synonyms (1R)-1-(L-alanylamino)-ethylphosphonic acid
ALAFOSFALIN
H-L-Ala-L-AlaP(OH)2
N-(S)-alanyl-(R)-1-aminoethanephosphonic acid
ALAPHOSPHIN
L-alanyl-L-1-aminoethylphosphonic acid
1R-1-(L-alanylamino)-ethanephosphonic acid
L-ALANYL-L-ALA(P)-OH
(S)-Alanyl-(R)-1-aminoethylphosphonic acid,Alafosfalin,Alaphosphin
((L)-(1-((N-L-alanyl)amino)ethyl))phosphonic acid
Description Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties[1].
Related Catalog
Target

Antibacterial[1]

In Vitro Alafosfalin is highly active against Escherichia coli and moderately active against Serratia, Klebsiella, Enterobacter, and Citrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus, Pseudomonas, and Acinetobacter[1].
In Vivo After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t1/2) of approximately 20 minutes[2]. Animal Model: Pairs of male SpragueDawley rats (250 to 350 g)[2] Dosage: 20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis) Administration: Administrated by s.c. Result: Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes.
References

[1]. H B Maruyama, et al. Alafosfalin, a New Inhibitor of Cell Wall Biosynthesis: In Vitro Activity Against Urinary Isolates in Japan and Potentiation With Beta-Lactams. Antimicrob Agents Chemother. 1979 Oct;16(4):444-51.

[2]. J G Allen, et al. Phosphonopeptides as Antibacterial Agents: Metabolism and Pharmacokinetics of Alafosfalin in Animals and Humans. Antimicrob Agents Chemother. 1979 Sep;16(3):306-13.
Molecular Formula C5H13N2O4P
Molecular Weight 196.14100
Exact Mass 196.06100
PSA 125.45000
LogP 0.76750
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases 22
RIDADR NONH for all modes of transport
HS Code 2931900090
Precursor  0

DownStream  1

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%
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