DC Chemicals Limited
China
Product Name: Cyclizine
Price: $Inquiry/1g
Purity: 98.0%
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Contact: Tony Cao

82-92-8

82-92-8 structure

Name: Cyclizine
Chemical Name: cyclizine
CAS Number: 82-92-8
Molecular Formula: C₁₈H₂₂N₂
Molecular Weight: 266.38100
Create Date: 2018-07-09 21:21:16
Modify Date: 2024-01-09 12:25:55

Name	cyclizine
Synonyms	Ciclizina Marzine N-benzhydryl-N'-methylpiperazine Valoid Bw 47-83 Marazine 1-Benzhydryl-4-methyl-piperazin Emoquil Nautazine Marezine Wellcome CYCLIZINE HCL 1-diphenylmethyl-4-methylpiperazine 1-benzhydryl-4-methyl-piperazine

Molecular Formula	C₁₈H₂₂N₂
Molecular Weight	266.38100
Exact Mass	266.17800
PSA	6.48000
LogP	2.89920

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6475000

CHEMICAL NAME :: Piperazine, 1-(diphenylmethyl)-4-methyl-

CAS REGISTRY NUMBER :: 82-92-8

BEILSTEIN REFERENCE NO. :: 0230441

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H22-N2

MOLECULAR WEIGHT :: 266.42

WISWESSER LINE NOTATION :: T6N DNTJ AYR&R& D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 126 mg/kg/6W-I

TOXIC EFFECTS :: Blood - agranulocytosis

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,174,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 147 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,218,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 450 mg/kg

SEX/DURATION :: female 10-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,323,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 450 mg/kg

SEX/DURATION :: female 10-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Effects on Newborn - stillbirth

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,323,1970 *** REVIEWS *** TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

Hazard Codes	T+
HS Code	2933599090

109-01-3

90-99-3

~30%

82-92-8

Literature: US2009/176792 A1, ; Page/Page column 26 ;

105-59-9

91-00-9

~18%

82-92-8

Literature: Journal of Organic Chemistry, , vol. 50, # 9 p. 1365 - 1370

110-85-0

776-74-9

74-88-4

~43%

82-92-8

Literature: Journal of the American Chemical Society, , vol. 119, # 14 p. 3288 - 3295

102552-76-1

82-92-8

Literature: BE539693 , ;

Precursor 8
109-01-3 90-99-3 105-59-9 91-00-9
110-85-0 776-74-9 74-88-4 102552-76-1
DownStream 2
841-77-0 139329-22-9

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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