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67-45-8

67-45-8 structure
67-45-8 structure
  • Name: Furazolidone
  • Chemical Name: furazolidone
  • CAS Number: 67-45-8
  • Molecular Formula: C8H7N3O5
  • Molecular Weight: 225.158
  • Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Aminopyridine
  • Create Date: 2018-02-06 08:00:00
  • Modify Date: 2025-08-20 07:22:39
  • Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines.
Name furazolidone
Synonyms 2-Oxazolidinone, 3-[[(1E)-(5-nitro-2-furanyl)methylene]amino]-
Furall
Bifuron
MFCD00010550
3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone
3-{(E)-[(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone
Furidon
Furazolidone
3-{[(E)-(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
Neftin
nf-180
Furazon
Furazol
Furaxon
Furox
3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone
EINECS 200-653-3
Description Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines.
Related Catalog
References

[1]. Jiang X, et al. A novel application of furazolidone: anti-leukemic activity in acute myeloid leukemia. PLoS One. 2013 Aug 9;8(8):e72335.
Density 1.7±0.1 g/cm3
Boiling Point 353.4±52.0 °C at 760 mmHg
Melting Point 254-256ºC (dec.)
Molecular Formula C8H7N3O5
Molecular Weight 225.158
Flash Point 167.5±30.7 °C
Exact Mass 225.038574
PSA 100.86000
LogP -0.49
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.670
Storage condition 0-6°C
Water Solubility formic acid: soluble50mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RQ3675000
CHEMICAL NAME :
2-Oxazolidinone, 3-((5-nitrofurfurylidene)amino)-
CAS REGISTRY NUMBER :
67-45-8
LAST UPDATED :
199806
DATA ITEMS CITED :
49
MOLECULAR FORMULA :
C8-H7-N3-O5
MOLECULAR WEIGHT :
225.18
WISWESSER LINE NOTATION :
T5OJ BNW E1UN- AT5NVOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
11 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression Blood - eosinophilia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2336 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1782 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
700 mg/kg
SEX/DURATION :
male 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
840 mg/kg
SEX/DURATION :
male 14 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 gm/kg
SEX/DURATION :
female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Mammal - domestic Leukocyte
DOSE/DURATION :
50 ug/L
REFERENCE :
RVMVAH Revue de Medecine Veterinaire (Toulouse). (Ecole Nationale Veterinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France) V.89(2)- 1937- Volume(issue)/page/year: 126,1611,1975 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,141,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 31,141,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84610 No. of Facilities: 258 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 3165 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84610 No. of Facilities: 1628 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 16392 (estimated) No. of Female Employees: 2949 (estimated)
Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H361
Precautionary Statements P281
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn:Harmful
Risk Phrases R62
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS RQ3675000
HS Code 2934992000
5407-76-1 structure

5407-76-1

~%

67-45-8 structure

67-45-8

Literature: Journal of the American Chemical Society, , vol. 77, p. 2282
405-22-1 structure

405-22-1

~%

67-45-8 structure

67-45-8

Literature: Journal of the American Chemical Society, , vol. 77, p. 2282
80-65-9 structure

80-65-9

698-63-5 structure

698-63-5

~%

67-45-8 structure

67-45-8

Literature: Journal of the American Chemical Society, , vol. 77, p. 2277,2280, 2281
75-44-5 structure

75-44-5

28127-20-0 structure

28127-20-0

~%

67-45-8 structure

67-45-8

Literature: Journal of the American Chemical Society, , vol. 77, p. 2277,2280, 2281
109-84-2 structure

109-84-2

105-58-8 structure

105-58-8

~%

67-45-8 structure

67-45-8

Literature: Journal of the American Chemical Society, , vol. 77, p. 2277,2280, 2281
109-84-2 structure

109-84-2

92-55-7 structure

92-55-7

~%

67-45-8 structure

67-45-8

Literature: Industrial and Engineering Chemistry, , vol. 47, p. 358,359 Przemysl Chemiczny, , vol. 36, p. 400 Chem.Abstr., , p. 3140
6270-33-3 structure

6270-33-3

~%

67-45-8 structure

67-45-8

Literature: US2898335 , ;
698-63-5 structure

698-63-5

109-84-2 structure

109-84-2

~%

67-45-8 structure

67-45-8

Literature: US2742462 , ;
HS Code 2934992000
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