DC Chemicals Limited
China
Product Name: Secoisolariciresinol Diglucoside
Price: $800.0/250mg $1600.0/1g $500.0/100mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Seco-isolariciresinol diglucoside
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: TIANFUCHEM Seco-isolariciresinol diglucoside
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

148244-82-0

148244-82-0 structure

Name: Secoisolariciresinol Diglucoside
Chemical Name: Seco-isolariciresinol diglucoside
CAS Number: 148244-82-0
Molecular Formula: C₃₂H₅₀O₁₈
Molecular Weight: 722.73
Catalog: Biochemical Carbohydrate Double sugar
Create Date: 2018-04-08 08:00:00
Modify Date: 2024-01-05 13:31:19
seco-Isolariciresinol Diglucoside, a synthetic lignin, which is derived from the natural plant flaxseed. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, and NF-κB activation in macrophages (MF). seco-Isolariciresinol Diglucoside also activates Nrf2.

Name	Seco-isolariciresinol diglucoside
Synonyms	β-D-Glucopyranoside, (2R,3R)-4-(β-D-glucopyranosyloxy)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butyl (2R,3R)-4-(β-D-Glucopyranosyloxy)-2,3-bis(4-hydroxy-3-methoxybenzyl)butyl β-D-glucopyranoside SecoisolariciresinolDiglucoside Flaxseed Extract Secoisolariciresinol Diglucosi Secoisolariciresinol diglucoside

Description	seco-Isolariciresinol Diglucoside, a synthetic lignin, which is derived from the natural plant flaxseed. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, and NF-κB activation in macrophages (MF). seco-Isolariciresinol Diglucoside also activates Nrf2.
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR) Research Areas >> Infection Natural Products >> Phenylpropanoids
Target	NLRP3 NF-κB Nrf2
In Vitro	seco-Isolariciresinol Diglucoside (LGM2605) is a nontoxic lignan with anti-inflammatory and antioxidant properties and is evaluated for protection from asbestos in murine peritoneal macrophages (MF). seco-Isolariciresinol Diglucoside significantly reduces NLRP3 ranging from 40 to 81%, IL-1β by 89-96%, and TNFα by 67-78%, as well as activated NF-κB by 48-49% while decreasing levels of nitrates/nitrites by 85-93%. seco-Isolariciresinol Diglucoside reduces asbestos-induced NLRP3 expression, proinflammatory cytokine release, NF-κB activation, and nitrosative stress in macrophages (MF) supporting its possible use in preventing the asbestos-induced inflammatory cascade leading to malignancy. seco-Isolariciresinol Diglucoside inhibits NF-κB expression and prevents asbestos-induced iNOS expression and nitric oxide production by murine peritoneal macrophages. seco-Isolariciresinol Diglucoside activates Nrf2 and induces the expression of cellular antioxidant and detoxification enzymes[1].
References	[1]. Pietrofesa RA, et al. The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages. Oxid Med Cell Longev. 2017;2017:7395238.

Density	1.5±0.1 g/cm3
Boiling Point	989.2±65.0 °C at 760 mmHg
Molecular Formula	C₃₂H₅₀O₁₈
Molecular Weight	722.73
Flash Point	552.0±34.3 °C
PSA	257.68000
LogP	-2.79
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.655
Storage condition	2-8°C

RIDADR	NONH for all modes of transport
HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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