DC Chemicals Limited
China
Product Name: Ratic
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Ranitidine
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Ranitidine hydrochloride HCL form II USP
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66357-35-5

66357-35-5 structure

Name: Ratic
Chemical Name: ranitidine
CAS Number: 66357-35-5
Molecular Formula: C₁₃H₂₂N₄O₃S
Molecular Weight: 314.404
Catalog: API Digestive system medication Inhibition of gastric acid secretion
Create Date: 2018-02-08 08:00:00
Modify Date: 2024-01-02 17:35:39
Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine is a weak inhibitor of CYP2C19 and CYP2C9[1][2].

Name	ranitidine
Synonyms	Taural Sostril Terposen Trigger U1tidine Ranitidine Zantic MFCD00081180 RANITIDINE USP EINECS 266-332-5 U1cex Zantae

Description	Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine is a weak inhibitor of CYP2C19 and CYP2C9[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Endocrinology Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Anti-infection >> Bacterial
Target	H2 Receptor:3.3 μM (IC50) CYP2C19 CYP2C9
References	[1]. A W Herling, et al. Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions. 1987 Feb;20(1-2):35-9. [2]. A Leucuta, et al. A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact. 2004;20(4):273-81. [3]. Antonio Francesco Ciccaglione, et al. Pylera® plus ranitidine vs Pylera® plus esomeprazole in first-line treatment of Helicobacter pylori infection: Two pilot studies. Helicobacter. 2019 Oct;24(5):e12606.

Density	1.2±0.1 g/cm3
Boiling Point	437.1±45.0 °C at 760 mmHg
Melting Point	69-70°C
Molecular Formula	C₁₃H₂₂N₄O₃S
Molecular Weight	314.404
Flash Point	218.2±28.7 °C
Exact Mass	314.141266
PSA	111.56000
LogP	1.23
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.559
Storage condition	Desiccate at +4°C
Water Solubility	24.7 mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM6556500

CHEMICAL NAME :: 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)th io)ethyl)-N'-methyl- 2-nitro-

CAS REGISTRY NUMBER :: 66357-35-5

LAST UPDATED :: 199703

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C13-H22-N4-O3-S

MOLECULAR WEIGHT :: 314.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 12 mg/kg/2D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - interstitial nephritis Blood - other changes Skin and Appendages - dermatitis, allergic (after topical exposure)

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 12,67,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 93 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2018 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 884 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 25,749,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4613602

Safety Phrases	S22-S24/25
WGK Germany	2
RTECS	KM6557000
HS Code	2932999099

Precursor 5
66356-53-4 7440-44-0 13623-94-4 66357-07-1
75-52-5
DownStream 5
66357-59-3 15433-79-1 112233-24-6 112233-23-5
112233-25-7

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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