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61263-49-8

61263-49-8 structure
61263-49-8 structure
  • Name: vitexilactone
  • Chemical Name: [(1R,3R,4R,4aS,8aS)-4-hydroxy-3,4a,8,8-tetramethyl-4-[2-(5-oxo-2H-furan-3-yl)ethyl]-2,3,5,6,7,8a-hexahydro-1H-naphthalen-1-yl] acetate
  • CAS Number: 61263-49-8
  • Molecular Formula: C22H34O5
  • Molecular Weight: 378.502
  • Catalog: Natural product Moss
  • Create Date: 2018-06-08 19:05:50
  • Modify Date: 2024-01-01 23:59:55
  • Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer[1][2].
Name [(1R,3R,4R,4aS,8aS)-4-hydroxy-3,4a,8,8-tetramethyl-4-[2-(5-oxo-2H-furan-3-yl)ethyl]-2,3,5,6,7,8a-hexahydro-1H-naphthalen-1-yl] acetate
Synonyms (1R,3R,4R,4aS,8aS)-4-Hydroxy-3,4a,8,8-tetramethyl-4-[2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl]decahydronaphthalen-1-yl acetate
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vitexilactone
UNII-8HP9QLE96R
(1R,3R,4R,4aS,8aS)-4-Hydroxy-3,4a,8,8-tetramethyl-4-[2-(5-oxo-2,5-dihydro-3-furanyl)ethyl]decahydro-1-naphthalenyl acetate
2(5H)-Furanone, 4-[2-[(1R,2R,4R,4aS,8aS)-4-(acetyloxy)decahydro-1-hydroxy-2,5,5,8a-tetramethyl-1-naphthalenyl]ethyl]-
Description Vitexilactone is a diterpenoid that can be isolated from the leaves of Vitex negundo L. Vitexilactone shows antimicrobial activity towards E. coli. Vitexilactone induces cell apoptosis and inhibits cell cycle of cancer cells. Vitexilactone can be used for the research of cancer[1][2].
Related Catalog
In Vitro Vitexilactone 对 E. coli 表现出显著的抗菌活性，MIC 值 >90 μg/mL[1]。 Vitexilactone (0-100 μg/mL; 17-24 h) 抑制哺乳动物癌细胞的增殖[2]。 Vitexilactone (25-100 μg/mL; 17 h) 高浓度时诱导细胞凋亡，低浓度时抑制细胞周期 G0/G1期，在 tsFT210 和 K562 细胞中[2]。 Cell Proliferation Assay[2] Cell Line: tsFT210 and K562 cells lines Concentration: 0-100 μg/mL Incubation Time: 17-24 hours Result: Inhibited cell proliferation of mammalian cancer cells with IC50 values of 86.9 and 57.9 μg/mL for tsFT210 and K562 cells, respectively. Apoptosis Analysis[2] Cell Line: tsFT210 and K562 cell lines Concentration: 25-100 μg/mL Incubation Time: 17 hours Result: Induced cell apoptosis of tsFT210 with a MIC value of 25 μg/mL. Cell Cycle Analysis[2] Cell Line: tsFT210 and K562 cell lines Concentration: 25-100 μg/mL Incubation Time: 17 hours Result: Inhibited G0/G1 phase of cell cycle with the dose ranges of 50-6.25 μg/mL in tsFT210 cells.
References

[1]. Sichaem J, et al. A new labdane-type diterpenoid from the leaves of Vitex negundo L. Nat Prod Res. 2021 Jul;35(14):2329-2334.  

[2]. Li WX, et al. Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L. J Asian Nat Prod Res. 2005 Apr;7(2):95-105.  

Density 1.1±0.1 g/cm3
Boiling Point 501.5±40.0 °C at 760 mmHg
Molecular Formula C22H34O5
Molecular Weight 378.502
Flash Point 166.6±20.8 °C
Exact Mass 378.240631
PSA 72.83000
LogP 3.69
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.529
Hazard Codes Xi

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title: CAS No. 61263-49-8 | Chemsrc address: https://www.chemsrc.com/en/baike/88615.html

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