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6192-62-7

6192-62-7 structure
6192-62-7 structure
Name Tomatidin Hydrochloride
Synonyms MFCD00133866
(3β,5α,25S)-Spirosolan-3-ol hydrochloride (1:1)
Spirosolan-3-ol, (3β,5α,25S)-, hydrochloride (1:1)
Tomatidine hydrochloride
Description Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.
Related Catalog
Target

p65

JNK

In Vitro Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity[1].
Cell Assay RAW 264.7 cells, derived from murine macrophages, are cultured in DMEM supplemented with 10% endotoxin-free, heat-inactivated fetal calf serum, Penicillin (100 units/mL), and Streptomycin (100 μg/mL) in a 5% CO2 atmosphere at 37 °C in a humidified incubator. For all assay, cell is plated at 2×105 cells/cm2 in culture dishes or plates. Treatment with vehicle (0.1% DMSO or 0.1% ethanol), test compounds and/or LPS is carried out under serum-free conditions[1].
References

[1]. Chiu FL, et al. Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Lett. 2008 Jul 9;582(16):2407-12.
Boiling Point 551.1ºC at 760 mmHg
Melting Point 281-284ºC (dec.)
Molecular Formula C27H46ClNO2
Molecular Weight 452.113
Flash Point 287.1ºC
Exact Mass 451.321716
PSA 41.49000
LogP 6.49760
Storage condition -20℃
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
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title: CAS No. 6192-62-7 | Chemsrc address: https://www.chemsrc.com/en/baike/879952.html

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