28448-04-6

28448-04-6 structure

Name: 3-Nitrocoumarin
Chemical Name: 3-nitrochromen-2-one
CAS Number: 28448-04-6
Molecular Formula: C₉H₅NO₄
Molecular Weight: 191.14
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phospholipase
Create Date: 2017-12-13 07:45:44
Modify Date: 2025-08-25 17:37:45
3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor[1].

Name	3-nitrochromen-2-one
Synonyms	3-nitro-chromen-2-one 3-nitro-2H-chromen-2-one 3-nitrocoumarin HMS545H12

Description	3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase Research Areas >> Others
Target	PLC-γ[1].
References	[1]. Ward PD, et al. Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins. J Biol Chem. 2002 Sep 20;277(38):35760-5.

Hazard Codes	Xi

2483-57-0

90-02-8

~84%

28448-04-6

626-35-7

90-02-8

~29%

28448-04-6

Literature: Gavrilova; Semichenko; Korotchenko; Suboch Russian Journal of Organic Chemistry, 2008 , vol. 44, # 4 p. 624 - 625

626-35-7

89-95-2

28448-04-6

Literature: Versleijen, Jos P. G.; Van Leusen, Albert M.; Feringa, Ben L. Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5803 - 5806

13218-13-8

90-02-8

28448-04-6