6022-96-4

6022-96-4 structure

Name: a-D-Xylofuranose,1,2-O-(1-methylethylidene)-, 5-benzoate
Chemical Name: [(3aR,5R,6S,6aR)-6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate
CAS Number: 6022-96-4
Molecular Formula: C₁₅H₁₈O₆
Molecular Weight: 294.30
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2017-11-23 23:46:05
Modify Date: 2025-08-25 20:39:41
5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	[(3aR,5R,6S,6aR)-6-hydroxy-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate
Synonyms	(4-hydroxy-7,7-dimethyl-2,6,8-trioxabicyclo[3.3.0]oct-3-yl)methylbenzoate 5-O-benzoyl-1,2-O-isopropylidene-D-xylofuranose α-D-Xylofuranose, 1,2-O-(1-methylethylidene)-, 5-benzoate 5-O-Benzoyl-1,2-O-isopropylidene-α-D-xylofuranose [(3aR,5R,6S,6aR)-6-Hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate [(3aR,5R,6S,6aR)-6-Hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methylbenzoat

Description	5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

98-88-4

20031-21-4

~94%

6022-96-4

Literature: Johnson; Bhumralkar; De Clercq Nucleosides and Nucleotides, 1995 , vol. 14, # 1-2 p. 185 - 194

769-78-8

20031-21-4

~96%

6022-96-4

532-20-7

~77%

6022-96-4

Literature: Puech, Frederic; Gosselin, Gilles; Imbach, Jean-Louis Tetrahedron Letters, 1989 , vol. 30, # 24 p. 3171 - 3174

19820-60-1

20031-21-4

~65%

6022-96-4

Literature: Mota, Antonio J.; Robles, Rafael; De Cienfuegos, Luis Alvarez; Lamenca, Alberto Tetrahedron Letters, 2004 , vol. 45, # 17 p. 3349 - 3353

20881-04-3

6022-96-4

Literature: Koth, Daniel; Fiedler, Andrea; Scholz, Sandy; Gottschaldt, Michael Journal of Carbohydrate Chemistry, 2007 , vol. 26, # 5-6 p. 267 - 278

58-86-6

6022-96-4

Literature: Koth, Daniel; Fiedler, Andrea; Scholz, Sandy; Gottschaldt, Michael Journal of Carbohydrate Chemistry, 2007 , vol. 26, # 5-6 p. 267 - 278

532-32-1

6022-96-4

Literature: Mota, Antonio J.; Robles, Rafael; De Cienfuegos, Luis Alvarez; Lamenca, Alberto Tetrahedron Letters, 2004 , vol. 45, # 17 p. 3349 - 3353

20031-21-4

6022-96-4