2998-57-4

2998-57-4 structure

Name: estramustine
Chemical Name: estramustine
CAS Number: 2998-57-4
Molecular Formula: C₂₃H₃₁Cl₂NO₃
Molecular Weight: 440.40300
Catalog: API Antineoplastic agents Alkylating agent
Create Date: 2018-03-31 08:00:00
Modify Date: 2025-08-21 11:32:25
Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1].

Name	estramustine
Synonyms	Estradiol 3-(N,N-bis(2-chloroethyl)carbamate) [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate Estramustina estradiol-3-bis(2-chloroethyl)carbamate Estramustinum MFCD00866377 Estracyt EINECS 221-076-3 17beta-Estradiol 3-(bis(2-chloroethyl)carbamate)

Description	Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	Tubulin 1[1]
References	[1]. Dahllöf B, et al. Estramustine depolymerizes microtubules by binding to tubulin. Cancer Res. 1993 Oct 1;53(19):4573-81.

Hazard Codes	Xn

2998-56-3

50-28-2

~76%

2998-57-4

Literature: Sk, Ugir Hossain; Dixit, Deobrat; Sen, Ellora European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 47 - 57

62899-40-5

2998-57-4

Literature: Journal of medicinal chemistry, , vol. 10, # 2 p. 172 - 174