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China
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24159-07-7

24159-07-7 structure

24159-07-7 structure

Name: Febrifugine
Chemical Name: Febrifugine
CAS Number: 24159-07-7
Molecular Formula: C₁₆H₁₉N₃O₃
Molecular Weight: 301.340
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-06-20 11:28:28
Modify Date: 2024-01-02 11:31:19
Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].

Name	Febrifugine
Synonyms	3-{3-[(2S,3R)-3-Hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one 3-[b-Keto-g-(3-hydroxy-2-piperidyl)propyl]-4-quinazolone (2S-trans)-3-[3-(3-Hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone 3-{3-[(2S,3R)-3-Hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quinazolinone b-Dichroine β-Dichroine 4(3H)-Quinazolinone, 3-[3-[(2S,3R)-3-hydroxy-2-piperidinyl]-2-oxopropyl]- Febrifugine febrifungine Febrifugine (8CI)

Description	Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77. [2]. McLaughlin NP, et al. The chemistry and biology of febrifugine and halofuginone. Bioorg Med Chem. 2014 Apr 1;22(7):1993-2004.

Density	1.4±0.1 g/cm3
Boiling Point	508.2±60.0 °C at 760 mmHg
Melting Point	139-140°; mp 154-156°
Molecular Formula	C₁₆H₁₉N₃O₃
Molecular Weight	301.340
Flash Point	261.1±32.9 °C
Exact Mass	301.142639
PSA	84.22000
LogP	-0.04
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.673
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA3450000

CHEMICAL NAME :: 4(3H)-Quinazolinone, 3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, (2S-trans)-

CAS REGISTRY NUMBER :: 24159-07-7

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H19-N3-O3

MOLECULAR WEIGHT :: 301.38

WISWESSER LINE NOTATION :: T66 BVN ENJ C1V1- BT6NTJ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 71,1048,1949

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,867,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 161,400,1948

HS Code	2933990090

Precursor 8
1213768-41-2 330798-23-7 32434-44-9 244056-97-1
304436-17-7 304436-18-8 304436-19-9 304436-20-2
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%