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487-36-5

487-36-5 structure
487-36-5 structure
  • Name: Pinoresinol
  • Chemical Name: (+)-pinoresinol
  • CAS Number: 487-36-5
  • Molecular Formula: C20H22O6
  • Molecular Weight: 358.385
  • Catalog: Natural product Lignans
  • Create Date: 2018-06-24 01:37:10
  • Modify Date: 2025-08-20 17:45:30
  • Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis[1][2].
Name (+)-pinoresinol
Synonyms (+)-PINORESINOL
4,4'-(1S,3aR,4S,6aR)-Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diylbis(2-methoxyphenol)
Phenol, 4,4'-[(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2-methoxy-
Pinoresinol
Description Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis[1][2].
Related Catalog
In Vitro Pinoresinol facilitated death-inducing signaling complex formation to trigger a caspase-8-dependent apoptotic cascade activation in TRAIL-resistant glioblastoma cells[2].
References

[1]. Schroeder FC, et al. Pinoresinol: A lignol of plant origin serving for defense in a caterpillar. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15497-501.

[2]. Lee SR, et al. Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis. Sci Rep. 2019 Sep 18;9(1):13505.
Density 1.3±0.1 g/cm3
Boiling Point 556.5±50.0 °C at 760 mmHg
Melting Point 121 °C
Molecular Formula C20H22O6
Molecular Weight 358.385
Flash Point 290.4±30.1 °C
Exact Mass 358.141632
PSA 77.38000
LogP 1.54
Appearance white to tan
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.598
Storage condition ?20°C
Water Solubility DMSO: ≥6mg/mL
Hazard Codes Xi
RIDADR NONH for all modes of transport
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title: CAS No. 487-36-5 | Chemsrc address: https://www.chemsrc.com/en/baike/834156.html

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