DC Chemicals Limited
China
Product Name: MTOB
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: sodium 4-(methyl thio)-2-oxobutanoate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

51828-97-8

51828-97-8 structure

Name: MTOB
Chemical Name: sodium,4-methylsulfanyl-2-oxobutanoate
CAS Number: 51828-97-8
Molecular Formula: C₅H₇NaO₃S
Molecular Weight: 170.16200
Catalog: Research Areas Cancer
Create Date: 2018-05-14 08:00:00
Modify Date: 2024-01-02 13:19:26
MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines[1][2].

Name	sodium,4-methylsulfanyl-2-oxobutanoate
Synonyms	KMBA MFCD00010511 sodium 4-methylsulfanyl-2-oxo-butyrate UNII-2EZY36W75U Sodium 4-(methylthio)-2-oxobutanoate sodium 4-methylthio-2-oxobutyrate Fema No. 3881 4-Methylthio-2-oxobutanoic acid sodium salt

Description	MTOB sodium is a potent C-terminal binding protein (CtBP) inhibitor. MTOB sodium attenuates repetitive head injury-elicited neurologic dysfunction and neuroinflammation via inhibition of the transactivation activity of CtBP1 and CtBP2. MTOB sodium antagonizes the transcriptional regulatory activity of CtBP1 and CtBP2 by eviction from their target promoters in breast cancer cell lines[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	CtBP[1]
In Vitro	MTOB sodium (10 mM) causes significant derepression (P<0.05) of 40% of CtBP target genes (including FGF9, CTNNB1, CEBPB, et al.) in MCF-7 and 46% in MBA-MD-231; increases the pro-epithelial E-cadherin/Vimentin ratio while reducing the pro-mesenchymal CD44/CD24 ratio, with a more significant trend (P<0.05) in MCF-7[2].
In Vivo	MTOB sodium (860 mg/kg; IP, at 1 h and 18 h after the first injury) effectively suppresses the increases duration of righting reflex, and significantly decreased neurological severity score (NSS) scores[1]. Animal Model: C57BL/6 mice (traumatic brain injury)[1] Dosage: 860 mg/kg Administration: IP, at 1 h and 18 h after the first injury Result: Effectively suppressed the increased duration of righting reflex, and significantly decreased NSS scores.
References	[1]. Li H, et al. C-terminal binding proteins 1 and 2 in traumatic brain injury-induced inflammation and their inhibition as an approach for anti-inflammatory treatment. Int J Biol Sci. 2020 Feb 4;16(7):1107-1120. [2]. Di LJ, et al. Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nat Commun. 2013;4:1449.

Melting Point	>300ºC(lit.)
Molecular Formula	C₅H₇NaO₃S
Molecular Weight	170.16200
Exact Mass	170.00100
PSA	82.50000
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	UN 3335
HS Code	2930909090

Precursor 0
DownStream 3
63-68-3 59-51-8 583-91-5

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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