869802-58-4
869802-58-4 structure
- Name: A 841720
- Chemical Name: 3-(azepan-1-yl)-9-(dimethylamino)pyrido[1,2]thieno[3,4-d]pyrimidin-4-one
- CAS Number: 869802-58-4
- Molecular Formula: C17H21N5OS
- Molecular Weight: 343.44700
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2017-01-09 19:26:59
- Modify Date: 2025-08-27 15:37:01
-
A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research[1][2].
| Name | 3-(azepan-1-yl)-9-(dimethylamino)pyrido[1,2]thieno[3,4-d]pyrimidin-4-one |
|---|---|
| Synonyms | BU 224 hydrochloride |
| Description | A-841720 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Human mGluR1:10 nM (IC50) human mGluR5:342 nM (IC50) |
| References |
| Molecular Formula | C17H21N5OS |
|---|---|
| Molecular Weight | 343.44700 |
| Exact Mass | 343.14700 |
| PSA | 82.50000 |
| LogP | 2.64920 |
| RIDADR | NONH for all modes of transport |
|---|
| Precursor 4 | |
|---|---|
| DownStream 0 | |