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59-40-5

59-40-5 structure
59-40-5 structure
  • Name: Sulfaquinoxaline
  • Chemical Name: Sulfaquinoxaline
  • CAS Number: 59-40-5
  • Molecular Formula: C14H12N4O2S
  • Molecular Weight: 300.336
  • Catalog: API Synthetic anti-infective drugs Sulfonamides and synergists
  • Create Date: 2018-09-12 19:51:32
  • Modify Date: 2025-08-23 22:16:30
  • Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].
Name Sulfaquinoxaline
Synonyms sulfaquinoxaline
Benzenesulfonamide, 4-amino-N-2-quinoxalinyl-
Kokozigal
4-Amino-N-[(2E)-2(1H)-quinoxalinylidene]benzenesulfonamide
sulquin
N1-2-quinoxalylsulfanilamide
MFCD00055406
anti-k
EINECS 213-526-2
N1-(2-Quinoxalyl)sulfanilamide
sulfacox
sulphaquinoxaline
italquina
4-Amino-N-(2-quinoxalinyl)benzenesulfonamide
Benzenesulfonamide, 4-amino-N-[(2E)-2(1H)-quinoxalinylidene]-
sulfaline
4-Amino-N-(quinoxalin-2-yl)benzenesulfonamide
Compound 3-120
avicocid
SUQUIN
Description Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].
Related Catalog
Target

Bacterial, Parasite[1][2]

In Vivo Sulfaquinoxaline shows the presence of all antimicrobial residues at concentration higher than the drugs' maximum residue limit (MRL) of 100 μg/kg until two days after discontinuation of the medication[2].
Animal Admin For the depletion studies, 240 1-day-old Cobb chicks are used. The chickens are housed in pens that contains 30 birds each (10 birds/m2) and are provided ad libitum access to water and non-medicated feed. The chickens are randomly allocated into four experimental groups, labeled from A to D, containing 80 birds each. Chickens in group A form the untreated control group, whereas those in groups B, C and D are treated with 10 mg/kg bw of enrofloxacin, Sulfaquinoxaline or oxytetracycline, respectively, which is administered via drinking water from the 32nd to 34th day of breeding[1].
References

[1]. de Assis DC, et al. Evaluation of the Presence and Levels of Enrofloxacin, Ciprofloxacin, Sulfaquinoxaline and Oxytetracycline in Broiler Chickens after Drug Administration. PLoS One. 2016 Nov 15;11(11):e0166402.

[2]. Urbano VR, et al. Influence of pH and ozone dose on sulfaquinoxaline ozonation. J Environ Manage. 2017 Jun 15;195(Pt 2):224-231.
Density 1.5±0.1 g/cm3
Boiling Point 557.0±52.0 °C at 760 mmHg
Melting Point 247-2480C
Molecular Formula C14H12N4O2S
Molecular Weight 300.336
Flash Point 290.7±30.7 °C
Exact Mass 300.068085
PSA 106.35000
LogP 1.58
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.718
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WP2100000
CHEMICAL NAME :
Sulfanilamide, N(sup 1)-2-quinoxalinyl-
CAS REGISTRY NUMBER :
59-40-5
BEILSTEIN REFERENCE NO. :
0290026
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C14-H12-N4-O2-S
MOLECULAR WEIGHT :
300.36
WISWESSER LINE NOTATION :
T66 BN ENJ CMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MahWM# Personal Communication from W.M. Mahlburg, Hopkins Agricultural Chemical Co., P.O. Box 7532, Madison, WI 53707, Nov. 16, 1982 Volume(issue)/page/year: 16NOV1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A370,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9100 mg/kg/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,357,1944
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1400 mg/kg/14D-I
TOXIC EFFECTS :
Blood - hemorrhage Related to Chronic Data - death
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,357,1944 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1518 No. of Facilities: 615 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 901 (estimated)
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H302-H317-H334
Precautionary Statements P261-P280-P342 + P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22;R42/43
Safety Phrases S22-S36/37-S45
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS WP2100000
HS Code 2935009090
6632-67-3 structure

6632-67-3

~88%

59-40-5 structure

59-40-5

Literature: Li, Jian; Chen, Jing; Gui, Chunshan; Zhang, Li; Qin, Yu; Xu, Qiang; Zhang, Jian; Liu, Hong; Shen, Xu; Jiang, Hualiang Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 7 p. 2209 - 2224
5424-05-5 structure

5424-05-5

~%

59-40-5 structure

59-40-5

Literature: Bioorganic and Medicinal Chemistry, , vol. 14, # 7 p. 2209 - 2224
490-59-5 structure

490-59-5

~%

59-40-5 structure

59-40-5

Literature: Journal of the American Chemical Society, , vol. 66, p. 1957
85414-82-0 structure

85414-82-0

~%

59-40-5 structure

59-40-5

Literature: Journal of the American Chemical Society, , vol. 66, p. 1957
121-60-8 structure

121-60-8

~%

59-40-5 structure

59-40-5

Literature: Journal of the American Chemical Society, , vol. 66, p. 1957
1448-87-9 structure

1448-87-9

63-74-1 structure

63-74-1

~%

59-40-5 structure

59-40-5

Literature: Journal of the Chemical Society, , p. 2129,2132 US2675379 , ;
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
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