146369-65-5

146369-65-5 structure

Name: TIPP
Chemical Name: (2S)-2-[[(2S)-2-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoic acid
CAS Number: 146369-65-5
Molecular Formula: C₃₇H₃₈N₄O₆
Molecular Weight: 634.72
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2019-01-09 18:19:40
Modify Date: 2025-08-26 22:09:04
TIPP is a potent and selective δ-opioid antagonist with a Ki value of 1.22 nM[1].

Name	(2S)-2-[[(2S)-2-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoic acid
Synonyms	Tyr-tic-phe-phe-OH H-Tyr-Tic-Phe-Phe-OH L-Phenylalanine,L-tyrosyl-L-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-phenylalanyl TIPP

Description	TIPP is a potent and selective δ-opioid antagonist with a Ki value of 1.22 nM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
References	[1]. Schiller PW, et al. The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists. Biopolymers. 1999;51(6):411-25.