25953-14-4

25953-14-4 structure

Name: Thymidine,5'-deoxy-5'-iodo-
Chemical Name: 5'-iodo-5'-deoxythymidine
CAS Number: 25953-14-4
Molecular Formula: C₁₀H₁₃IN₂O₄
Molecular Weight: 352.13
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-11-22 19:49:46
Modify Date: 2024-01-09 18:18:39
5′-Deoxy-5′-iodothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	5'-iodo-5'-deoxythymidine
Synonyms	5'-deoxy-5'-iodothymidine 5'-iodo-5'-deoxy-thymidine 5'-Jod-5'-desoxy-thymidin 5'-Deoxy-5'-iodo-D-thymidine

Description	5′-Deoxy-5′-iodothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

50-89-5

~77%

25953-14-4

Literature: Vernekar, Sanjeev Kumar V.; Qiu, Li; Zacharias, Jeana; Geraghty, Robert J.; Wang, Zhengqiang MedChemComm, 2014 , vol. 5, # 5 p. 603 - 608

21090-30-2

25953-14-4

Literature: Michelson; Todd Journal of the Chemical Society, 1955 , p. 816,822