DC Chemicals Limited
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Acenocoumarol
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152-72-7

152-72-7 structure

152-72-7 structure

Name: acenocoumarol
Chemical Name: acenocoumarol
CAS Number: 152-72-7
Molecular Formula: C₁₉H₁₅NO₆
Molecular Weight: 353.326
Catalog: API Blood system medication Anticoagulant and antiplatelet drugs
Create Date: 2018-08-14 08:51:14
Modify Date: 2024-01-04 11:22:25
Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist.

Name	acenocoumarol
Synonyms	UNII:I6WP63U32H 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one Trombostop EINECS 205-807-3 MFCD00137816 2H-1-Benzopyran-2-one, 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]- 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)- 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-(4-nitrophenyl)-3-oxobutyl)-, (±)- 3-(a-Acetonyl-p-nitrobenzyl)-4-hydroxycoumarin 4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one acenocoumarol 3-(a-p-Nitrophenyl-b-acetylethyl)-4-hydroxycoumarin

Description	Acenocoumarol is an anticoagulant that functions as a Vitamin K antagonist.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease

Density	1.4±0.1 g/cm3
Boiling Point	592.7±50.0 °C at 760 mmHg
Melting Point	196-199ºC
Molecular Formula	C₁₉H₁₅NO₆
Molecular Weight	353.326
Flash Point	312.3±30.1 °C
Exact Mass	353.089935
PSA	113.33000
LogP	3.15
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.656
Water Solubility	DMSO, heptane and xylene: ≥17mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN4900000

CHEMICAL NAME :: Coumarin, 3-(alpha-acetonyl-p-nitrobenzyl)-4-hydroxy-

CAS REGISTRY NUMBER :: 152-72-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H15-N-O6

MOLECULAR WEIGHT :: 353.35

WISWESSER LINE NOTATION :: T66 BOVJ DY1V1&R DNW& EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 513 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,3,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 11,85,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,6,1989 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 24 mg/kg

SEX/DURATION :: female 1-28 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: AFPEAM Archives Francaises de Pediatrie. (Doin Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1942- Volume(issue)/page/year: 36,63,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7380 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 239 (estimated) No. of Female Employees: 157 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P301 + P312 + P330-P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	63-22-36/37/38
Safety Phrases	26-36/37
RIDADR	UN 2811
RTECS	GN4900000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2932209090

1076-38-6 structure

1076-38-6

946-49-6 structure

946-49-6

~%

152-72-7 structure

152-72-7

152-72-7 structure

152-72-7

Literature: Angewandte Chemie - International Edition, , vol. 42, # 40 p. 4955 - 4957

946-49-6 structure

946-49-6

1076-38-6 structure

1076-38-6

~%

152-72-7 structure

152-72-7

152-72-7 structure

152-72-7

Literature: Bulletin of the Korean Chemical Society, , vol. 33, # 6 p. 1825 - 1826

1076-38-6 structure

1076-38-6

~%

152-72-7 structure

152-72-7

Literature: Tetrahedron Asymmetry, , vol. 12, # 5 p. 707 - 709

555-16-8 structure

555-16-8

~%

152-72-7 structure

152-72-7

Literature: Tetrahedron Asymmetry, , vol. 12, # 5 p. 707 - 709

Precursor 3
1076-38-6 946-49-6 555-16-8
DownStream 0

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%