Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Sodium butyrate
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sodium butanoate
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Sodium Butyrate
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Henan Tianfu Chemical Co., Ltd.
China
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156-54-7

156-54-7 structure

Name: Sodium butyrate
Chemical Name: sodium butyrate
CAS Number: 156-54-7
Molecular Formula: C₄H₇NaO₂
Molecular Weight: 110.087
Catalog: Organic raw materials Organometallic compound Organic sodium
Create Date: 2018-02-05 08:00:00
Modify Date: 2024-01-02 18:48:33
Butyric acid is a histone deacetylase (HDAC) inhibitor, with anti-tumor effects in several cancers.

Name	sodium butyrate
Synonyms	MFCD00002816 Butyrate sodium salt Natriumbutyrat Na butyrate EINECS 205-857-6 SODIUM BUTYRATE pure NAB BUTYRIC ACID NA Sodium butanoate SODIUM N-BUTYLATE SODIUMBUTYRATE,USP Sodium Butyrate sodium n-butyrate butyratesodium butyric acid sodium salt

Description	Butyric acid is a histone deacetylase (HDAC) inhibitor, with anti-tumor effects in several cancers.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Research Areas >> Cancer
Target	HDAC
In Vitro	Sodium Butyrate induces morphological changes, inhibits cell proliferation and impairs cell viability in NPC cells. Sodium Butyrate (1, 5, 10 mM) is cytotoxic to NPC cells, inducing a dose- and time-dependent decrease in cell viability, in both 5-8F and 6-10B cells. Sodium Butyrate induces nasopharyngeal carcinoma cell apoptosis by activating the mitochondrial apoptotic axis. Moreover, SOCE inhibition and disruption of the CRAC channel can attenuate the apoptosis induced by Sodium Butyrate[1]. Sodium butyrate significantly decreases cell viability, accompanied by reduced levels of p-mTOR and PCNA protein. Sodium butyrate, in a dose-dependent manner, induces cell cycle arrest in G0/G1 phase and reduces the numbers of cells in S phase. In addition, relative expression of p21, p27, and pro-apoptosis bak genes, and protein levels of p21Waf1/Cip1, p27Kip1, cyclinD3, CDK4, and Cleave-caspase3 are increased by higher concentrations of sodium butyrate (1, 5, 10 mM), and the levels of cyclinD1 and CDK6 are reduced by 5 and 10 mM butyrate[3].
In Vivo	Sodium Butyrate (300 mg/kg, s.c.) administration immediately after HI provided almost complete neuroprotection in comparison with non-treated animals. Sodium butyrate administration results in an increased number of microglial cells to 150% of vehicle-treated animals in the ipsilateral side. Sodium butyrate promotes the polarization of microglia from M1- to M2-like phenotype after neonatal hypoxia-ischemia[2]. Sodium butyrate (300 mg/kg, s.c.) in combination with AK-7 (20 mg/kg, i.p.) significantly alleviates this reduction of the time spent exploring new objects, ameliorates the reduction of the number of Ki67-positive cells and DCX-immunoreactive neuroblasts in the dentate gyrus of the mice. In addition, sodium butyrate reverses SIRT2-related age phenotypes[4].
Cell Assay	Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 µL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 µL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 µL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.
Animal Admin	Seven-day-old rat pups are subjected to unilateral carotid artery ligation followed by 60 min of hypoxia (7.6% O2). Sodium Butyrate (300 mg/kg) is administered in a 5-day regime with the first injection given immediately after hypoxic exposure. The damage of the ipsilateral hemisphere is evaluated by hematoxylin-eosin staining 6 days after the insult. Samples are collected at 24 and 48 h and 6 days.
References	[1]. Huang W, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017 Feb;13(2):921-929 [2]. Jaworska J, et al. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia. J Neuroinflammation. 2017 Feb 10;14(1):34 [3]. Qiu Y, et al. Effect of sodium butyrate on cell proliferation and cell cycle in porcine intestinal epithelial (IPEC-J2) cells. In Vitro Cell Dev Biol Anim. 2017 Jan 27 [4]. Jung HY, et al. Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation. Lab Anim Res. 2016 Dec;32(4):224-230 [5]. Wang P, et al. Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. Neurobiol Dis. 2017 Dec 14;111:12-25.

Density	0.987g/cm3
Boiling Point	164.3ºC at 760 mmHg
Melting Point	250-253 °C(lit.)
Molecular Formula	C₄H₇NaO₂
Molecular Weight	110.087
Flash Point	69.7ºC
Exact Mass	110.034370
PSA	40.13000
Vapour Pressure	1.35mmHg at 25°C
Stability	Stable. Incompatible with strong acids.
Water Solubility	soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ET6400000

CHEMICAL NAME :: Butyric acid, sodium salt

CAS REGISTRY NUMBER :: 156-54-7

LAST UPDATED :: 199803

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C4-H8-O2.Na

MOLECULAR WEIGHT :: 111.11

WISWESSER LINE NOTATION :: OV3 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Mammal - cattle Lymphocyte

DOSE/DURATION :: 4 mmol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 51,141,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82158 No. of Facilities: 22 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 184 (estimated) No. of Female Employees: 101 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S37/39-S26-S24/25
RIDADR	2820
WGK Germany	1
RTECS	ET6400000
HS Code	2915600000

302-84-1

246855-94-7

127-09-3

156-54-7

Detail

Literature: Tetrahedron Asymmetry, , vol. 22, # 13 p. 1473 - 1478

79-03-8

137-40-6

156-54-7

Literature: Journal of Fluorine Chemistry, , vol. 132, # 2 p. 107 - 113

141-75-3

1281943-44-9

1281943-45-0

156-54-7

Literature: Journal of Fluorine Chemistry, , vol. 132, # 2 p. 107 - 113

56-23-5

7732-18-5

71-36-3

156-54-7

Literature: Journal of the American Chemical Society, , vol. 61, p. 100

Precursor 6
302-84-1 79-03-8 141-75-3 56-23-5
7732-18-5 71-36-3
DownStream 10
33657-49-7 557-25-5 71-36-3 504-63-2
110-54-3 64-17-5 78-83-1 141-78-6
105-54-4 123-19-3

HS Code	2915600000
Summary	2915600000 butanoic acids and pentanoic acids and their salts and esters VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

156-54-7	270564-49-3
347840-05-5	204244-79-1
312623-84-0	286367-62-2
286367-75-7	53736-52-0
62601-04-1	286367-74-6